All issues > Volume 26(10); 1983

Case Report

J Korean Pediatr Soc. 1983;26(10):1024-1028. Published online October 31, 1983.

A Case of Trensient Myeloproliferative Disorder with Down Syndrome.

Dong Gyoon Kim¹, Jae Ho Lee¹, Jung Il Noh¹, Hyo Seop Ahn¹, Chang Yee Hong¹

¹Department of Pediatrics，College of Medicine, Seoul National University

Abstract

Transient myeloproliferative disorder has been reported in infants with Down syndrome. Infants with Down syndrome and this transient myeloproliferative disorder often present with signs and symptoms that are clinically and hematologically indistinguishable from congenital acute myelogenous leukemia. In contrast to congenital AML, complete clinical and hematological recovery occurs within weeks to months of diagnosis without any specific anti- leukemic treatment. A case of transient myeloproliferative disorder with Down syndrome in a 17 days old male is experienced and is reported with literature review. He showed jaundice, hepatosplen- omegaly and petechiae. Peripheral blood smear and bone marrow examination revealed a picture of leukemia. But clinical and hematological improvement occurred after 3 months without any specific anti-leukemic treatment.

Keywords :Transient myeloproliferative disorder; Down syndrome.