All issues > Volume 26(10); 1983

Original Article

J Korean Pediatr Soc. 1983;26(10):967-977. Published online October 31, 1983.

Hyperlipidemia and Hyperlipoproteinemia in Focal Segmental Glomerulosclerosis Nephrotic Syndrome.

Heui Jeen Kim¹, Kwang Wook Ko¹

¹Department of Pediatrics, College of Medicine, Seoul National University

Abstract

Sera obtained from 23 hospitalized patients with focal segmental glomerulosclerosis nephrotic syndrome which is confirmed by kidney biopsy, were analyzed for serum albumin, serum lipids, 24hr urine protein, creatinine clearance, HDL-cholesterol. In 19 of the patients lipoproteins were analyzed. the following results were obtained. 1) Serum phospholipid (PL) was increased whenever serum total cholesterol (TC) was increased but to a lesser degree. The ratio of TC/PL were greater than normal (Fig. 1). The relationship between TC and TG (triglyceride) was very irregular (Fig. 2). 2) Concentrations of serum cholesterol was related inversely to serum abumin levels (r=— 0.57, Fig. 3). The relationship between triglyceride and albumin was less regular than that of cholesterol(r= — 0.43, Fig. 5). 3) No significant correlation between serum lipids and the 24hr urine protein excretion or creatinine clearance was noted. 4) Serum lipoprotein patterns were determined in 19 patients. Fifteen of the 19 nephrotic patients had abnormal lipoprotein patterns. Half of the hyperlipoproteinemias were Fredrickson,type lb (Table 4). 5) HDL-cholesterol ievels were increased in 4 patients and decreased in 5 patients.

Keywords :Focal segmental glomerulosclerosis nephrotic syndrome; hyperlipidemia; hyperlipoproteinemia.