All issues > Volume 26(9); 1983

Case Report

J Korean Pediatr Soc. 1983;26(9):916-921. Published online September 30, 1983.

Nephrogenic Diabetes Insipidus occurred in 2 Brother.

Jin Heon Kim¹, Cheol Won Park¹, Bong Soo Lee¹, Chang Soo Ra¹

¹Department of Pediatrics, College of Medicine, Chosun University

Abstract

Nephrogenic diabetes insipidus is a congenital hereditary disorders in which the kidney do not respond to vasopressin, and the disease occurs principally in males and is probably inherited by Xlinked recessive mode. We experienced two cases of nephrogenic diabetes insipidus occurred in brothers. The clinical manifestations were extreme thirst and frequent urination of large volume of dilute urine, approximately 5,500ml per day with specific gravity 1.000. The diagnosis was made by water restriction and pitressin test. Administration of chlorothizide diuretics in combination with reduced sodium intake led to reduction in urinary volume and to increased urinaryconcentration. We report neprogenic diabetes insipidus with brief review of literatures.

Keywords :Nephrogenic diabetes insipidus.