All issues > Volume 26(8); 1983

Original Article

J Korean Pediatr Soc. 1983;26(8):770-777. Published online August 31, 1983.

Histological Study of Ductus Arteriosus Affected by Indomethacin in the Fetal Rates.

Young Sook Jang¹, Chang Yeoul Jeon¹, Heon Sook Lee¹, Jung Soo Kim¹, Moo Sam Lee²

¹Dept, of Pediatrics，Jeonbug National University Medical School
²Dept, of Anatomy, Jeonbug National University Medical School

Abstract

This work was perforrred for the observation of morphological changes and beginning portion of obliteration in ductus arteriosus. And also histological findings in ductus arteriosus affected by indomethacin (4ug/kg/day) were studied. The following results were obtained. In the process of obliteration, intimal pillow became irregular with the narrowing of the lumen and loose connective tissue was frequently filled into the lumen. In the tunica media there was marked increased of collagenous fibers and PAS positive materials, meanwhile elastic and muscle fibers were decreased. In ductus arteriosus of the 19th fetal rat after the injection of indomethacin into maternal peritoneal cavity in the 15th day of gestation, the walls were thickening and the lumens were narrower than those of same gestational age in normal development. Some cases of ductus arteriosus were striking in that there were folds of connective tissue projected into the lumen from the surface of the mound.

Keywords :Indomethacin, PDA.