All issues > Volume 26(3); 1983

Original Article

J Korean Pediatr Soc. 1983;26(3):257-264. Published online March 31, 1983.

Clinical Observation of Dds Induced Methemoglobinemia.

Hee Seon Auh¹, Kwan Hwooy Cho¹, Kir Young Kim¹, Duk Jin Yun¹, Sook Pyo Kwon²

¹Department of Pediatrics, Yonsei University College of Medicine
²Department of Preventive Medicine and Public Health, Yonsei University College of Medicine

Abstract

Various compounds activate the oxidation of hemoglobin. These include nitrites, sulfonamides, aniline derivatives, chlorates, quinones, acetanilid and phenacetin. The striking offender has been DDS in infancy and childhood who live in Kangwon Do, Korea. The common untoward effects of DDS are hemolytic anemia and methemoglobinemia. This clinical study was carried out for analysis on 57 cases which were diagnosed as DDS induced methemoglobinemia at the department of pediatrics in Wonju Christian Hospital during 4 years and 6 months, from Jan. 1, 1977 to June 30, 1981 The results were as follows： 1) DDS induced methemoglobinemia developed in 57 cases among 129 cases of total drugintoxication. 2) The intoxication showed the highest incidence in children before 6 year of age. 3) The dosage ingested was from 25 mg to 250 mg in 32 cases, but others were unknown. 4) Cyanosis occured in all cases. 5) The duration between DDS poisoning and the onset of symptoms was within 6 hours ins 60% of cases. 6) Any case did not show profound anemia. 7) The correlation coefficient was 0. 6 between the dosage and the methemoglobin level.

Keywords :Clinical observation; DDS; Methemoglobinemia