All issues > Volume 25(12); 1982

Original Article

J Korean Pediatr Soc. 1982;25(12):1252-1260. Published online December 31, 1982.

Clinical and Hematological Analysis on the 110 Cases of Childhood Leukemia.

Sang Choel Lee¹

¹Department of pediatrics，St. Benedict Hospital，Busan，Korea

Abstract

The author reviewed the clinical and hematological findings of the 110 children diagnosed as leukemia at pediatric departments, Busan National University and St. Benedict’s Hospital, Busan, during a period of 8 years arid 8 months from January 1973 to August 1981. The results obtained were summarized as follows: 1. Of the 110 chil-dhood leukemias, acute lymphoblastic type was most frequent(60.9%), iollowed by acute myeloblastic type(28.2%). And acute myelomonocytic leukemia(1.8%), ■erythroleukemia(2.7%), undifferentiated stem cell leukemia(1.8%), chronic leukemia(3.6%) and chronic myelocytic leukemia(0.9%) were very rare. 2. In childhood leukemias the ratio of male and female was 1.3 and the age group of 3 to 4 years most frequent (24.5%). 3. Of the 110 childhood leukemias, acute type was in 95.5% and chronic type only in 4.5 %，Under the age of 4 years, acute type was more frequent in male than female, while after the age 5 years both types occurred equally in male and female. 4.The duration of clinical manifestations before the diagnosis was within 1 month in 64.8% of the cases, followed by 2 to 5 months in 26.8%. Of the symptoms at the time of the amdission, pallor and bleeding were most frequent as 49.1% and 47.4% respectively. 5.In the acute lymphoblastic leukemia, hepatomegaly was in 68.3%, splenomegaly 69.3% and lymph node enlargement 46.0%, and in the acute myeloblastic leukemia, hepatomegaly was in 33.3%, splenomegaly 6.7% and lymphnode enlargement 10.0%. The signs were significantly differed between acute lymphoblastic type and acute myeloblastic type. 6.Of the peripheral blood examination, leukocyte count was over 50,000/mm in 25.5%, 20,000 to 50,000/mm in 21.7%, 5000 to 10,000/mm in 20.8% and under 5,000/mm in 14.2%. Hemoglobin, level was 4.1 to 8. Ogm% in 38.5%, 6.1 to 8. Ogn% in 26.0%, under 4.0 gm% in 16.3% and over 10.1 gm% in 10.6%, and erythrocyte sedimentation rate was 41 to 80 mm/ hr in 42.4%, over 100 rnrn/hr in 26.9% and under 20 mm/hr in 9.6%. Platelet count under 50,000/mm was in 40.2%, 50,000 to 100,000/mm in 30.4% over 200,000/mm in 3.3%, and reticulocyte count over 2.1% was only 9.5%.

Keywords :Leukemia; Type;Clinicalmanifestation; Laboratory finding.