All issues > Volume 25(9); 1982

Original Article

J Korean Pediatr Soc. 1982;25(9):880-887. Published online September 30, 1982.

The effect of vincristine and adriamycin on the phagocytic function of reticuloendothelial system of rats.

Hyun Suk Lee, Jong Soo Kim, Jung Soo Kim, Kyu Cha Kim, Ho Yeul Choi

¹Department of Pediatrics, Jeon Bug National University Medical School
²Department of Pathology, Jeon Bug National University Medical School

Abstract

This experiment was carried out to investigate the effects of anticancer drugs on the phagocytic function of reticuloendothelial system. The phagocytic activity was assessed by- means of carbon clearance method, after intravenous injection of vincristine(5 pg or 25 y^g/lOO gm of body weight) and adriamycin (70 pg or 350 ^g/100 gm of body weight) through one， two, and three times at the interval of one week, respectively. The change of liver, spleen, and body weight, and number of WBC in the peripheral blood are observed, also. The obtained results were as follows; A. In the vincristine treated groups, 1. Phagocytic function was not changed in. the single administered group. But in the group of two and three times administered, Phagocytic function was decreased compared with control group. 2. There is no significant difference compared with control group in the change of body weight and the ratio of liver weight to body weight. Atrophy of the spleen and decreased number of WBC were in proportion to treatment frequency, but not to dosage. B. In the adriamycin treated groups, 1. Phagocytic function was decreased in the entire experimental groups. These decreased effects were not related to frequency and dosage of administration. 2. The change of body weight and the ratio of liver weight to body weight were similar to control group. Atrophy of the spleen was in proportion to treatment frequency but not to dosage. Decrease of WBC count was more remarkable with increase of dosage and frequency.

Keywords :Reticuloendothelial system, Vincristine, Adriamycin.