All issues > Volume 25(8); 1982

Original Article

J Korean Pediatr Soc. 1982;25(8):781-786. Published online August 31, 1982.

Changes in Serum Complement and Immunglonulins following Cardiopulmonary Bypass.

Hong Jin Kim, Jun Hee Sul, Sung Kyn Lee, Dong Shik Chin, Kwang Ho Kim, Pill Whoon Hong

¹Department of Pediatrics, Yonsei University College of Medicine, Korea.
²Department of Thoracic Cardiovascular surgery, Yonsei University College of Medicine, Korea.

Abstract

Clinical problem occuring in the early post operative period after cardiopulmonary bypass may ne related to the altered function of capillary bed which was affected by activation of complement system. This is so called post perfusion syndrome. We selected 20 patients with confirmed congenital heart disease by cariac catheterization. We studied the changes in the C3 , immunolglobulins, total protein, and WBC count while performing open heart surgery. The results were as followed. 1. C3 level was lowest during cardiopulmonary bypass and returned to the normal level after 8 days. 2. Each immunoglobulin level decreased just after cardiopulmonary bypass, especially the IgG level, and immunoglobulins slowly returned to the normal range after 8 days. 3. Serum total protein level and electrophoretic fractions were comperatively reduced as much as immunoglobulin levels. 4. WBC count was lower just before cardiopulmonary bypass than baseline.

Keywords :Cardiopulmonary bypass;Complement system;Immunoglobulin;Oxygenator;Post perfusion syndrome;Blood gas interface