All issues > Volume 25(6); 1982

Original Article

J Korean Pediatr Soc. 1982;25(6):554-559. Published online June 30, 1982.

The Effects of Phenobarbital and Theophylline on the Phagocytic Function of Reticuloendothelial System of Rats.

Soo Chul Cho¹, Hyun Suk Lee¹, Kyu Cha Kim¹, Ho Yeul Choi²

¹Department of Pediatrics, Jeon Bug National University Medical School, Korea.
²Department of Pathology, Jeon Bug National University Medical School, Korea.

Abstract

This experiment was carried out to investigate the effects of depressor and stimulator of central nervous system on the reticuloendothelial phagocytic function in vivo. The phagocytic activity was assessed by means of carbon clearance method after intra-muscular adimnistration of phenobarbital(1mg/0.2 ml of normal saline/100 gm of body weight) and intravenous administ-ration of theophylline(1 mg/0.2 ml of normal saline/100 gm of body weight) into rats. The obtained results were as follows; 1. In the groups administrered with phenobarbital, the alteration in the phagocytic activity wi-thin three hours after administration was decreased compared with the normal and control gro-up, but thereafter, it was increased progressively to the normal level by 12 hours after administr-ation. 2. In the groups administered with theophylline, the alteration in the phagocytic activity within one hour after adminstration was increased compared with normal and control group, but after that decreased gradually to the normal level by 12 hours after injection. 3. From these results, it is concluded that stimulation of central nervous system may increa-se the phagocytic activity and depression of central nervous system may decrease the phagocy-tic activity of reticuloendothelial system.

Keywords :Pathophysiology of RES