All issues > Volume 25(1); 1982

Original Article

J Korean Pediatr Soc. 1982;25(1):52-57. Published online January 31, 1982.

Late Hemorrhagic Disease of Infancy due to Vitamin K Dependent Factor Deficiency.

Kang Il Lee¹, Yong Soon Kim¹, Sang Bum Lee¹, Ja Hoon Koo¹

¹Department of Pediatrics, School of Medicine, Kyungpook National University, Taegu, Korea.

Abstract

A clinical study was done on 9 children with 10 episodes, who were admitted to our pediatric ward under the diagnosis of late hemorrhagic disease of infancy due to vitamin K dependent factor deficiency. Study period was past 2 years, from September 1979 to May 1981. The following results were obtained. This disorder occurred most frequently during early infancy, with male predominence, male female ratio being 4:1. And breast feeding was noted in 6, with history of previous medication for URI in 7. GIT was the most common site of bleeding occurring in 9 cases, followed by CNS in 3, skin in 1 and nose in 1. Anemia, probably due to blood loss, was seen in 8 cases, and dehydration, oral thrush, fever, irritability, mental change and convulsion were seen in small number of cases. Initial laboratory findings showed prolonged PT and PTT with normal platelet count in all cases. After vitamin K therapy, PT and PTT became normal in majority of cases. Prompt response to vitamin K therapy within 24 hours was noted in 6, prolonged response over 3 days in 2, and one patient showed recurrence at 2(1/2) months after complete recovery from first episode.

Keywords :Late hemorrhagic disease of infancy;vitamin K deficiency