All issues > Volume 24(5); 1981

Case Report

J Korean Pediatr Soc. 1981;24(5):485-491. Published online May 15, 1981.

Two Cases of IgA Nephropathy.

Ho Jin Lee¹, Woon Sik Kim¹, Don Hee Ahn¹, Keun Chan Sohn¹, Hyun Soon Lee²

¹Department of Pediatrics, National Medical Center Seoul, Korea.
²Department of Pathology, Seoul National University, Medical College, Korea.

Abstract

Two cases of IgA nephropathy in an 11-year-old girl(Case I) and a 10-year-old boy(Case II) were presented. Case I, an 11-year-old schoolgirl, had recurrent painless hematuria of 6-month duration which began with URI symptoms at the onset. No edema was noted and urine volume was sufficient throughout the course. Mild proteinuria had been noted from time to time. Blood pressure was 140/90mmHg on admission but dropped soon to normal. Percutaneous renal biop-sy revealed proliferative focal glomerulosclerosis on light microscopy, IgA(+++) deposition in mesangium and subendothelium on immunofluorescent study, and election dense deposit in the mesangium on electron microscopy. Case II, a 10-year-old schoolboy, had suffered from symptomless hematuria of 3-month duration. The onset developed with skin infection, the 2nd relapse with otitis media and the 3rd with URI like symptoms. Other lab, findings were all within normal limit. Renal biopsy revealed minor change with segmental focal glomerulosclerosis on light microscopy, mesangial deposition of IgA(+++) & C3(+) on immunofluorescent study, and electron lense deposit in the mesangium on electron microscopy.

Keywords :Recurrent hematuria;focal glomerulonephritis;IgA nephropathy