All issues > Volume 24(5); 1981

Original Article

J Korean Pediatr Soc. 1981;24(5):459-465. Published online May 15, 1981.

Comparison of Theraputic Effects for Shigellosis Between Rifampin and Other Antimicrobial Agents.

Jong Seung Kim, Sung Won Kang, Kyn Duck Shin, Poong Man Lee

¹Department of Pediatrics, Catholic Medical College, Seoul, Korea.

Abstract

A) Bacteriological study and sensitivity test against antimicrobial agents were made on 126 cases of infantile and childhood shigellosis treated at pediatric epartment of St. Vincent hospital from April, 78 to September, 80. The results are follows: 1. Sh. flexneri was most frequently isolated(86.5%) and the next was Sh. sonnei(13.5%). 2. The percentage of resistant strains against antimicrobial agents. Ampicillin: 95.2% Carbenicillin : 90.5% Cephalothin: 78.6% Choloramphenicol: 95.2% Gentamicin: 20.6% Kanamycin: 23.8% Lincomycin: 100% Methicillin: 100% B) The effect of rifampin on bacteriological cure and clinical course in group B shigellosis of sixty-four hospitalized children from one year to five years old age were compared with other antibiotics. gentamicin, ampicillin and trimethoprim-sulfamethoxazole. Based on our study, rifampin was most effective drug in curing of clinical symptoms of shigellosis and eradicating the organisms from stool, and gentamicin was similar effect. Trimethoprim-sulfamethoxazole twas less effective than rifampin and gentamicin, but more effective than ampicillin which has no appreciable effect on the course of shigellosis.

Keywords :Rifampin;Shigellosis;Antimicrobial agents;Therapeutic effects