All issues > Volume 23(10); 1980

Original Article

J Korean Pediatr Soc. 1980;23(10):791-797. Published online October 15, 1980.

Therapeutic Effect of Rifampin in Shigellosis.

Chul Lee, Jun Hee Sul, Pyung Kil Kim, Duk Jin Yun

¹Department of Pediatirics, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Twenty one infants and children were entered into the study protocol when bacteriologic diagnosis of shigellosis was made by stool culture indenification. Fifteen patients were treated at Inje Hospital in Kangwon Do and six patients were treated at Severance Hospital in Seoul. Susceptibility studies were revealed that ampicillin was resistant in all cases. Gentamicin and Panimycin which are aminoglycosides were quite effective. But their use was limited because of their nephrotoxicity and those antibiotics should be used only by parenteral route. A daily dose of 20microgram per kilogram of body weight of rifampin was given by mouth divided every 6 hrs for 7 days routinely except 2 cases. After that follow up stool culture were performed on 13 patient. The results were negative except one case. There was no untoward reaction of rifampin during therapy except for the red coloring of urine and stool. To prevent developing the resistance of shigella to rifampin, it is necessary to confirm that negative conversion of stool cultures has been achieved. Our experience should encourge the use of rifampin in the treatment of shigellosis.

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