All issues > Volume 21(6); 1978

Original Article

J Korean Pediatr Soc. 1978;21(6):433-439. Published online June 30, 1978.

Antltoxln response to diphtheria and tetananus vaccine.

Chang Joo Kim

¹Dept. of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.

Abstract

An attempt has been made to evaluate diphtheria and tetanus antitoxin response to diphtheria and tetanus toxoid as pressently marketed in Korea. A total of 80 infants divided in two groups according to doses of vaccine, were studied One group of 30 infants (group I ) received 1, 2 or 3 doses of D. P. T. vaccine (0.3ml, each) at approximately monthly interval. 1) In control group of 19 infants not immunized, the protective level of diphtheria antitoxin was found in 36.8% of infants, and the protective level of tetanus antitoxin was found in 5.3% of infants. These finding suggested the antitoxin level which was passively transmitted from the mother. 2) The frequency of diphtheria and tetanus vaccination correlates with antitoxin level, but there was no difference in antitoxin response between group I or group 11. 3) The antitoxin response were more excellant in infants given same dose of vaccine divided into multiple dose. 4) In both group I and 11, 100% of infants achieved protective level of diphtheria (0.03u/ml) and tetanus antitoxin (0.1u/ml) after 3 primary vaccination.

Keywords :