All issues > Volume 34(12); 1991

Original Article

J Korean Pediatr Soc. 1991;34(12):1745-1752. Published online December 31, 1991.

A case of benign recurrent intrahepatic cholestasis.

Jae Hong Park¹, Sung Sub Sim¹, Soo Young Kim¹, Hee Joo Jeon¹, Chan Yung Kim¹

¹Department of Pediatrics, School of Medicine, Pusan National University, Pusan, Korea

Received: June 3, 1991;  Accepted: July 19, 1991.

Abstract

The clinical picture of beingn recurrent intrahepatic cholestasis (BRIC) consists of multiple epi- sodes of cholestatic jaundice without extrahepatic bile duct obstruction. Since first description by Summerskill and Walshe in 1959, almost 100 patients with BRIC have been described. The mechanism involved in the initiation and perpetution of an episode of cholestasis are unknown. Altered bile acid metabolism has been proposed to play a role in pathophysiology of the diseases. The authors recently experienced a case of BRIC in a 15-year-old boy, who had four episodes of recurrent attack of cholestatic jaundice during 38 months. The case is reported with the brief review of the literatures.

Keywords :Benign recurrent intrahepatic cholestasis