HepB, hepatitis B vaccine; BCG, Bacille Calmette Guérin vaccine; DTaP, diphtheria-tetanus-acellular pertussis vaccine; IPV, inactivated poliovirus vaccine; Hib, Haemophilus influenzae type b vaccine; PCV, pneumococcus protein conjugate vaccine; RV, rotavirus vaccine; IIV, inactivated influenza vaccine; HepA, hepatitis A vaccine; MMR, measles-mumps-rubella vaccine; Var, varicella vaccine; IJEV, inactivated Japanese encephalitis vaccine; LJEV, live Japanese encephalitis vaccine; Tdap, adolescent adult type tetanus-diphtheria-acellular pertussis vaccine; HPV, human papillomavirus vaccine.

^* Combination vaccines are available for HepB, DTaP, IPV, Hib vaccines. When administering combination vaccines, the minimum age for administration is the oldest age for any of the individual components. The minimum interval between doses is equal to the greatest interval of any of the individual components.

^† Rotavirus vaccine is an optional vaccine.

^a) HepB: Administer monovalent HepB at 0, 1, and 6 months of age; administer the third dose at least 8 weeks after the second dose and at least 16 weeks after the first dose, and no earlier than age 24 weeks. Administer the first dose according to the maternal hepatitis B surface antigen (HBsAg) status as follows: (a) If maternal HBsAg is positive, administer HepB and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth at different sites. (b) If maternal HBsAg status is unknown, administer HepB within 12 hours of birth and determine maternal HBsAg status as soon as possible. If maternal HBsAg is positive, also administer HBIG as soon as possible, but no later than age 7 days. (c) If maternal HBsAg is negative, administer HepB within 24 hours of birth.

^b) BCG: Administer BCG vaccine to neonates at birth through age 4 weeks. Infants over 3 months old require a tuberculin skin test before BCG vaccination.

^c) DTaP: Administer a 5-dose series of DTaP vaccine at ages 2, 4, and 6 months as primary series, and at 15 through 18 months and 4 through 6 years as boosters.

^d) IPV: Administer a 4-dose series of IPV at ages 2, 4, 6–18 months as primary series, and at 4 through 6 years as a booster.

^e) Hib: Administer a 4-dose series of Hib at ages 2, 4, 6 months as primary series, and at 12 through 15 months as a booster.

^f) PCV: Administer a 4-dose series of PCV at ages 2, 4, 6 months as primary series, and at 12 through 15 months as a booster.

^g) RV: The first dose of any RV vaccines can be administered as early as at 6 weeks of age. The maximum age for the first dose in the series is 14 weeks 6 days; vaccination should not be initiated for infants aged 15 weeks 0 days or older. For Rotarix (GSK, Middlesex, UK), administer a 2-dose series at 2 and 4 months of age. For RotaTeq (MSD, NJ, USA), administer a 3-dose series at 2, 4, and 6 months of age. The minimum interval between any doses is 4 weeks, and the maximum age for the final dose in the series is 8 months 0 days.

^h) IIV: Administer the IIV annually to all children aged 6 months through 12 years anytime during an influenza season, preferably before the increase of incidence. Additionally, administer influenza vaccine to caregivers and family members of children aged 0 through 59 months, children and adolescents 5 years and older who have any underlying medical conditions at high risk for complications from influenza, the caregivers of high-risk children and adolescents, and all people who opt for the vaccine. Administer 2 doses (separated by at least 4 weeks) to children younger than 9 years who are receiving IIV for the first time. Administer 1 dose to children and adolescents aged 9 years and older.

ⁱ⁾ HepA: Initiate the 2-dose HepA series at 12 through 23 months, and separate the 2 doses by 6 to 18 months in accordance with the products.

^j) MMR: Administer a 2-dose series of MMR at ages 12 through 15 months and at 4 through 6 years. Administer 1 dose of monovalent measles vaccine (or MMR) to infants aged 6 through 11 months when a measles outbreak occurs in the community. These children should be revaccinated with 2 doses of MMR, and the first dose should be administered at age 12 through 15 months and the second dose at age 4 through 6 years. The second dose may be administered before age 4 years with an interval of 4 weeks or more from the first dose in special situations.

^k) Var: Administer a single dose of Var to all children aged 12 through 15 months. The second dose of vaccine may be administered to children aged 12 months to 12 years who attend daycare centers, schools, or facilities where chicken pox is prevalent, provided at least 3 months have elapsed since the first dose.

^l) JEV: The first dose of any JEV, which is a 5-dose series of IJEV or a 2-dose series of LJEV, may be administered to children aged 12 through 23 months. If IJEV is used, administer 2-dose primary series at an interval of 7 to 30 days and administer booster doses at 12 months after the second dose, at ages 6 and 12 years, respectively. If LJEV is used, administer the second dose at least 12 months after the first dose.

^m) Tdap: Administer 1 dose of Tdap to adolescents aged 11 through 12 years who are fully immunized with the DTaP. Administer tetanus and diphtheria toxoid (Td) as boosters every 10 years thereafter.

ⁿ⁾ HPV: Administer a 2-dose series of either Cervarix (GSK, Rixensart, Belgium) or Gardasil (MSD) at 6-month interval for all girls aged 11–12 years. Administer a 3-dose series of HPV for girls with immunocompromising conditions or those who are 15 years (14 years for Gardasil) or older at initial vaccination, Cervarix with 0-, 1-, and 6-month schedule or Gardasil/Gardasil9 with 0-, 2-, and 6-month schedule.

PCV10, pneumococcal conjugate 10-valent vaccine; PCV13, pneumococcal conjugate 13-valent vaccine.

^* A vaccine series does not need to be restarted, regardless of the time that has elapsed between doses. For additional information regarding each vaccine, vaccination providers should refer to appropriate part of the Korean Pediatric Society Immunization Guideline or the insert paper for each vaccine.

^a) Hepatitis B vaccine: Unvaccinated children or adolescents should complete a 3-dose series. Minimum age at the third dose is 24 weeks.

^b) Diphtheria, tetanus toxoid, and acellular pertussis (DTaP) vaccine: The fifth dose of the DTaP vaccine is not necessary if the fourth dose was administered at age 4 years or older.

^c) Inactivated poliovirus vaccine (IPV): In the first 6 months of life, minimum age and minimum intervals are only recommended if the person is at risk of imminent exposure to circulating poliovirus. The final dose in the series should be administered on or after the fourth birthday and at least 6 months after the previous dose. The fourth dose is not necessary if the third dose was administered at age 4 years or older and at least 6 months after the previous dose. If both the oral poliovirus vaccine (OPV) and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child’s current age.

^d) Haemophilus influenzae type b (Hib) vaccine: For unvaccinated children aged 15 through 59 months, administer only 1 dose. Hib vaccine is not recommended for healthy children 5 years or older.

^e) Pneumococcal conjugate vaccine (PCV): For unvaccinated children aged 24 through 59 months, administer only 1 dose. PCV is not recommended for healthy children 5 years or older.

^f) Rotavirus (RV) vaccine: The first dose of any RV vaccines can be administered as early as at 6 weeks of age. According to the product, administer a 2-dose (Rotarix, GSK, Middlesex, UK) or 3-dose series (Rotateq, MSD, NJ, USA). The minimum interval between any doses is 4 weeks, the maximum age for the first dose in the series is 14 weeks 6 days, and the maximum age for the final dose in series is 8 months 0 days.

^g) Hepatitis A vaccine: Children should receive a second dose 6 to 18 months after the first dose.

^h) Measles, mumps, rubella (MMR) vaccine: Administer the second dose at age 4 through 6 years. However, the second dose may be administered at least 4 weeks after the first dose in special situations.

ⁱ⁾ Varicella vaccine: For children aged less than 13 years without evidence of immunity for varicella zoster, administer only 1 dose. For adolescents aged 13 years or older without evidence of immunity for varicella zoster, administer 2 doses with a 4- to 8-week interval. The second dose of vaccine may be administered to children aged 12 months to 12 years who attend facilities where chicken pox is prevalent, provided at least 3 months have elapsed since the first dose.

^j) Japanese encephalitis vaccine (JEV): If the third dose of inactivated JEV was administered at age 4 through 9 years, the fourth dose may be administered as a final dose at age 12 years. If the third dose of inactivated JEV was administered at age 10 years or more, an additional dose is not necessary. If live attenuated JEV is used, administer the second dose at least 12 months after the first dose.

^k) Tetanus and diphtheria toxoid and acellular pertussis (Tdap)/tetanus and diphtheria toxoid (Td) vaccine: Persons aged 7 years and older who are not fully immunized with DTaP vaccine should receive Tdap vaccine as 1 dose (preferably the first) in the catch-up series and if additional doses are needed, use the Td vaccine.

^l) Human papillomavirus (HPV) vaccine: Administer the 2nd dose as a final dose for girls who received 1st dose at the age younger than 15 years (14 years for Gardasil [MSD]) at minimal interval of 5 months (6 months for Gardasil). For girls with immunocompromising conditions or those who are 15 years (14 years for Gardasil) or older at initial vaccination, administer the 2nd dose 1 month after the 1st dose of Cervarix (GSK, Rixensart, Belgium) and 2 months after the 1st dose of Gardasil/Gardasil9. Administer the 3rd dose for all HPV vaccines 5 months after the 1st dose. Minimal intervals between the 1st–2nd, 2nd–3rd, and 1st–3rd doses are 4 weeks, 12 weeks, and 5 months, respectively.