All issues > Volume 16(5); 1973

Case Report

J Korean Pediatr Soc. 1973;16(5):388-391. Published online May 31, 1973.

Treatment of Vasopressin-Sensitive Diabetes Insipidus with Chlorpropamide

Choon Ji Suh¹, Bang Sup Lee¹, Chung II Kim¹, Churl Young Chung¹

¹Department of Pediatrics, Catholic Medical College Seoul, Korea

Abstract

Oral chlorpropamide therapy was assessed in 9 years-old male who entered with the complaints of polyuria, polydipsia and nocturia for 9 months. A significant reduction in urine vloume and increase in urine specific gravity occurred by its use. Mean 24 hour urine output during control periods was 5,460 ml (range, 5,300~5,700 ml) and mean urine specific gravity was 1; 005 (range, 1, 003~1, 007) on the time of admission. On chlorpropamide therapy, mean output fell to 1, 810 ml (range, 1, 200~2, 500 ml) and mean specific gravity rose to 1, 013 (range 1, 011~1,014). For many children with vase pressin -sensitive diabetes insipidus, chlorpropamide seems to be an effe- ctive form of therapy. The most recent experimental evidence suggests that the antidiuretic action of the drug may be due to an effect on the renal tubule, where by the latter’s sensitivity to small amounts of vasopressin may be enhanced.

Keywords :