All issues > Volume 10(6); 1967

Original Article

J Korean Pediatr Soc. 1967;10(6):311-320. Published online June 30, 1967.

Clinical Observation of Aplastic Anemia

Ja Hwan Kim¹, Bo Kyung Kim¹, Yee Ja Kim¹, Young Un Moon¹, Duk Jin Yun¹

¹Department of Pediatrics,Yonsei University, College of Medicine

Abstract

This paper deals with a group of 22 patients diagnosed at Severance Hospital between 1959 and 1965 as having aplastic anemia. Age incidence in the group of patients was 7 to 14 years except for one case. There was a striking difference in sex incidence, 16 cases were in males and 6 cases in females. The chief complaints in 16 patients at admission were severe hemorrhage, purpure, and anemia. The periperal blood was characterized by a pancytopenia, macrocytic, and normocytic in some patients. Coomb’s test was done in 6 of the 22 patients, none of whom showed positive findings. Bone marrow showed hypocellularity (less than 20 per cent of the normal cellularity) and fatty infiltration. The underlying causes of marrow insufficiency in 19 patients was not precisely defined, but Chinese drugs were suspected as causative agents in patients. In 2 patients Chinese drugs and Chlorampenicol were suspected. Chlorampenicol was definitely the causative agent in 3 patients. All the aplastic anemia patients were treated with tranfusion of blood, and corticosteroid combined with tespsterone. Fifteen of the patients ultimately died. Seven childrens are still living, 2 of them are recovered completely, four patients are clinically improved. One patient shows no response to treatment.

Keywords :