All issues > Volume 10(6); 1967

Original Article

J Korean Pediatr Soc. 1967;10(6):325-332. Published online June 30, 1967.

Guanine Deaminase Activity in the Cerebroapinal Fluid and its Isozymic Nature of the Mentally Retarded Child

Jung-Ai Park¹, Ja-Hwan Kim¹, Ok-Ja Cho², Sung-Wun Kim²

¹Department of Pediatrics,Yonsei University, Medical School
²Department of Biochemistry, Seoul University, Medical School

Abstract

1.Guanine deaminse (GDA) activities in the cerebrospinal fluid of the normal and mentally retarded children (cerebral palsy), with the IQ below 25, were analyzed, and the multiple forms of GDA of both groups were compared by means of the starch gel electrophoresis and chemical assay of the enzyme. 2.The normal activity in the cerebrospinal GDA of the child is 1.45土0.71 unit/L., whereas the activity of the mentally retarded child is 0.53±0.23 unit/L. 3.The cerebrospinal fluid of both groups appears to have at least 4 isozymes, and the repression of the cerebrospinal GDA activity in the mentally retarded is probably attributed to the decrease in the activities of isozymes of low electrophoretic mobilities in either direction of the starch gel electrophoresis.

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