All issues > Volume 9(4); 1966

Original Article

J Korean Pediatr Soc. 1966;9(4):227-236. Published online July 31, 1966.

C-Reactlve Protein In Various Infectious Diseases in Children

Dong Won Chun¹, Byung Youn Lee¹, Mahn Kyoo Yang²

¹Department of Pediatrics, Han II Hospital
²Department of Pediatrics Seoul City Children s Hospital

Abstract

The C-reactive protein, an acute phase protein, is an abnormal protein absent from normal human serum. It is, in all likelihood, a globulin formed by the body in response to various non-specific stimuli such as an infections, tissue necrosis, trauma, neoplasm and granuloma formation. The existence of this protein was first recognized by Tillet and Francis in 1930, as a result of its property of reacting to form a precipitate in the presence of the somatic C-polysaccharide of the pneumococcus. Serum C-reactive protein determination on total 288 sera from 255 patients with infectious diseases and allied conditions were done in the pediatric ward of Han-Il Hospital and Seoul City Children’s Hospital during the period from May 1, 19G3 to September 30, 1965. A comparison with patient’s temperature, leucocyte count, erythrocyte sedimentation rate and percentage of neutrophil polymorphonuclear leucocytes was also made in those cases. The summary of the results are as follows; 1) The incidence of positive .reactions was high in the sera of patients with rheumatic fever empyema, scarlet fever, bacterial pneumonia and diphtheria. 2) The intensity and the incidence of positive reactions of the sera of patients with infections ca-used by Gram-positive cocci revealed higher than that caused by Gram-negative cocci. 3)The incidence of positive reactions was high in the sera obtained within two. weeks after the onset of illness. 4) The presence of fever and elevated E.S.R. had a close relationship with the positive reactions. 5) There were many cases of positive reactions, even though the leucocyte counts and the percentage of neutrophil polymorphonuclear leucocytes were within normal range. 6) The results of this study were discussed and compared with previously puublished reports.

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