All issues > Volume 18(6); 1975

Original Article

J Korean Pediatr Soc. 1975;18(6):434-442. Published online June 30, 1975.

Studies on Serum Proteins by Electrophoresis in the Renal Disease

Kwang Chung Kim¹, Young Won Kim¹, Joo Ryong Kim¹

¹Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea

Abstract

We studied serum protein fractions by Cellulose-Acetate Membrane Immunoelectrophoresis, which were included 80 cases of acute glomerulonephritis and 7 cases of nephrotic syndrome, and compared with 20 cases of normal healthy children as control group. The results were as follows; 1.In 80 cases of acute lomerulonephritis, generally the distribution of serum protein fractions were summerized as follows; Albumin, arand /3-globulin were decreased ' slightly and. arglobulin increased slightly, but ^-globulin was increased markedly than control group. Serum protein fractions were compared by severity of disease (Group I to IV): Group I showing normal or only slightly elevated BUN and blood pressure; Group II showing markedly increased BUN and decreased urinary output but normal or only slightly elevated blood pressure; Group IH showing markedly increased blood pressure but normal or slightly :elevated BUN; Group IV showing markedly increased BUN and blood pressure and diminished urinary output, and may complicate with hypertensive encephalopathy, cardiac failure and renal failure. In Group I to III, no significant changes in fraction levels except 7-globulin which was markedly increased in Group I and III. But Group IV revealed 47. Z% of Albumin for 58.2% of controlgroup, 8.4% of /3-globulin for 11.7% of control group, and 29. 2% of 7-globulin for 5.5% of control group. 2.In 7 cases of nephrotic syndrome, total protein, albumin, i-and y-globulin were decreased, and a2 and /9-globulin were increased. Significant changes in serum total protein showed 5. 0gm% for 7.26. gm % of control group, and a2-globulin showed 28.1% for 9.56% of control group, which were more marked changes in nephrotic syndrome. 3. In control group, our studies for serum protein fractions were revealed almost sameas other reports

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