All issues > Volume 18(11); 1975

Original Article

J Korean Pediatr Soc. 1975;18(11):801-807. Published online November 30, 1975.

Clinical Observation of serum Proteins by Cellulose-acetate Electrophoresis in Virus Hepatitis

Kwang Chung Kim¹, Hyung Sun Yoon¹

¹Department of Pediatrics, College of Medicine, Hanyang University Seoul, Korea

Abstract

We studied total protein and serum protein fractions by cellulose-acetate membrane electrophoresis in 40 cases of viral hepatitis. The results were as follows: 1.The distribution of serum protein fractions on admission: a1-globulin revealed 3.44% for 5.41% of control group, but total protein, albumin, a2-, B- and r-globulin revealed minimal changes generally. 2.Age and Sex distribution: In sex distribution, r-globulin revealed 20.8% in females for 17.7% of males, but other fractions revealed normal ranges. In age distribution, total protein and r-globulin were lowest in group of one to three years and these were gradually in creased with aging, but other fractions were in normal ranges. 3.Electrophoretic patterns in relation to Icterus: In pre-icteric phase, arglobulin was decreased, and y-globulin was increased. In icteric phase a1-and a2-globulin were decreased, and r-globulin was increased slightly. 4.Electrophoretic patterns associated with clinical course: On admission, total protein, albumin, a1-and a2-globulin revealed lower limit of control group, 7-globulin revealed upper limit of control group, and S-GPT values revealed 125 units or more in 5 cases of patient. One week later after initiation of treatment, all the fractions revealed improvement, and S-GPT values were decreased than admission day in all cases.

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