All issues > Volume 17(10); 1974

Original Article

J Korean Pediatr Soc. 1974;17(10):683-687. Published online October 31, 1974.

On the Permeability of INH through Blood-Brain Barrier

Joong Sik Kim¹, Young Pyo Hong²

¹Department of Pediatrics, College of Medicine, Kyung-Hee University
²Department of Internal Medicine, College of Medicine, Kyung-Hee University

Abstract

Serum and cerebrospinal fluid INH levels were studied in tuberculous and non tuberculous meningitis cases following oral administration of INH 4 mg. per kg. of body weight. The measurements were done by the biological method. The INH levels 1 hour after administration were about half of serum in prolonged convulsion and tuberculous meningitis cases. Two hours after administration, the cerebrospinal fluid levels in normal children showed only one third ofsurum. Whereas in meningitis and prolonged convulsion cases, the INH levels in cerebrospinal fluid were same concentration as serum.

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