All issues > Volume 15(3); 1972

Original Article

J Korean Pediatr Soc. 1972;15(3):223-228. Published online March 31, 1972.

An Influences of Prednisolone and Carbon Tetrachloride on Transaminase Activity in Rabbits

Yong Han Chung¹

¹Dept, of Pediatrcis, Seoul National University College, of Medicine

Abstract

The author investigated the change of serum, liver and heart transaminase activity in rabbits after adminstraion of predisolone and carbon tetrachloride. In this eperiment, rabbits with average body weight" of 1. 8kg were chocen and were divided into three groups: a group treated with carbon tetrachlcricfe： only, prednisolone only, and both of carbon tetrachloride and prednisolone. The results of this investigation were as follows: 1) The serum G.O.T. & G.P.T. activities of normal rabbits are 20±2. 3 units, 10±2 units respectively and those of 1 gm wet liver are 230,000±40, 000, 150, 000±30, 000 & these of lgm wet heart, are- 65, 000±12, 000, 28,000±4,000 units. 2) The transaminse activity of rabbit serum treated with carbon tetrachloride only, is remarkably increased, while that of liver is decreased. 3) The G.O.T. value of rabbit liver treated with prednisolone only is also elevated, on the other hand” the G.O.T. value of it seemed to be slightly elevated and those of serum and heant are not changed. 4) The transaminase activitias of rabbit serum and liver treated with prednisolone and carbon/ tetrachloride are simillar to those one treated with carbon tetrachoride only.

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