All issues > Volume 15(5); 1972

Original Article

J Korean Pediatr Soc. 1972;15(5):412-415. Published online May 31, 1972.

Comparison of Efficacy of Various Oral - Hypoglycemic Agents on Diabetes Insipidus

Heung Kyu Kim¹, Yang Hyun Park¹, En Yul Yum¹, Ki Bok Kim¹

¹Department of Pediatrics, Kwangju Christian Hospital

Abstract

The efficacy of three oral hypoglycemic agents, all sulfonylurea derivatives (Chlorpropamide, Tolbutamide and Tolazamide) were compared in the case of a 6-year-old girl suffering from diabetes insipidus. Chlorpromide was demonstrated to be the most effective, Tolbutamide slightly effective, and Tolazamide lacked antidiuretic action. Comparison of molecular structures of these agents revealed that replacement of Cl in para-position with methyl radical did not greatly influence the antidiabetic efficacy, whereas replacing the propylradical with other complex radicals markedly affects the efficacy.

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