All issues > Volume 12(8); 1969

Case Report

J Korean Pediatr Soc. 1969;12(8):445-454. Published online August 31, 1969.

Investigation on Extrapulmonary Oxygenation of Hydrogen Peroxide and Oxygen

Duk Jin Yun¹

¹Department of Pediatrics, Yonsei University College of Medicine Seoul, Korea

Abstract

Investigation on extrapulmonary oxygenation was performed in dogs and rabbits by intestinal perfusion of hydrogen peroxide and oxygen. For the single administration, 0. 4% hydrogen peroxide can be given with a dose of 10 ml. per kilogram of body weight safely by enema preferably without doing any enema before the procedure, which would give maximum oxygenation in both portal vein and inferior venacava without forming gas emboli. Higher than this concentration would cause gas bubbles in portal vein. In the serial administration, 0. 2% hydrogen peroxide can be given by enema alternately exchanging the intestinal contents with 10 to 15 minutes intervals, preferably with human whole blood (1. 0 ml. per kilogram of body weight) to have a prolonged higher oxygenation in portal vein, inferior vena cava and femoral artery, which would not cause gas emboli in portal vein. The above concentrations of hydrogen peroxide could be utilized in pediatric practice if proved these would not form methemoglobin in the blood.

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