All issues > Volume 12(11); 1969

Case Report

J Korean Pediatr Soc. 1969;12(11):639-648. Published online November 30, 1969.

Cushing’s Syndrome in Infancy

Pyung Kil Kim¹, Ki Sub Chung¹, Duk Jin Yun¹, Sang Hyon Suh², Sang Ho Cho³

¹Department of Pediatrics Yonsei University College of Medicine Seoul, Korea
²Department of Surgery Yonsei University College of Medicine Seoul, Korea
³Department of Pathology Yonsei University College of Medicine Seoul, Korea

Abstract

There are little reports on the Cushing’s syndrome in children, especially in infancy in Korea. We have found recently a case of Cushing’s syndrome in infancy arising from a female infant. She has been complained from eleven month of age with general obesity including buffalo hump, excessive weight: gain, hirsutism and polyphgagia. Laboratory tests revealed that no thymic shadow in her chest X-ray, retarded bone age, hypertension,increased urinary excretion of 17-OHCS and 17-KS and eosinopsnia but no evidence of osteoporosis iir her long bone series. Two-days dexamethasone test were done and it was found that there were no response to administration of dexamethasone in her urinary excretion of 17-OHCS. IVP study showed that left kidney was displaced to downward than right side and an hen-egg size-radio-opaque shadow on the top of the left kidney. The tumor was removed successfully by anterior transabdominal approach and that was found as a benign adenoma by microscopic study. Hypertension, eosinopenia and hypokalemia were returned to normal level from 3 days after surgery but urinary 17-OHCS and 17-KS were returned to normal from two week after surgery. The literature about Cushing’s syndrome in infancy were reviewed and compaired with our case.

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