All issues > Volume 13(1); 1970

Original Article

J Korean Pediatr Soc. 1970;13(1):29-32. Published online January 31, 1970.

Chloramphenicol Levels in Cerebrospinal Fluid of Purulent Meningitis Children

Min Hwa Park¹

¹Department of Pediatrics, Chonnam University Medical School Kivang-ju, Korea

Abstract

The level of chloramphenicol in cerebrospinal fluid was studied in 10 cases of purulent meningitis with single intramuscular injection of chloramphenicol 100 mg/kg. The level of chloramphenicol in cerebrospinal fluid reached maximal concentration two hours after the intramuscular injection, maintained the effective level until 5 hours, and then progressively decreased. The level of cerebrospinal fluid chloramphenicol was about a half that of plasma level. It was shown from the above data that intramuscular injection of chloramphenicol should be repeated with interval of five to six hours for maintenance of effective therapeutic level.

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