All issues > Volume 13(6); 1970

Original Article

J Korean Pediatr Soc. 1970;13(6):337-344. Published online June 30, 1970.

Cytogentic Survey of Children with Mental Retardation

Hyung Ro Moon¹

¹Department of Pediatrics, College of Medicine, Seoul National University

Abstract

Seven children with Down’s syndrome, five boys and two girls, were included to cytogenetic survey. All of the children were clinically diagnosed by the presence of various combinations of microsymptoms or stigmata frequently observed in Down’s syndrome. To supply additional evidence for the diagnosis, data on the direct observation of dermatoglyphic patterns were also recorded. Chromosomal analyses revealed diploid number of 47 with trisomy-21 chromosome constituent in all except for one boy whose karyotype demonstrated 46, XY, D—,t (Dq Gq)+. Some of the pertinent cytogenetic and mental retardation were mentioned in the review.

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