All issues > Volume 13(11); 1970

Original Article

J Korean Pediatr Soc. 1970;13(11):633-638. Published online November 30, 1970.

Treatment of diabetes insipidus with chlorpropamide

Kibok Kim¹, Kyu-Hae Chung¹, Yang Hyun Park¹, Kyung Woo Cho², Young Johang Kook²

¹Dept, of Pediatrics, Kwangju Christian Hospital
²Dept, of Pharmacology, Chonnam Univ. Med. School

Abstract

In two cases of diabetes insipidus (a five-year-old girl and a eight-year-old boy), oral administration of chlorpropamide in doses of 125~250 mg per day produced marked antidiuresis and concentration of urine. It was noted that the agent was effective also in the vasopressin-insensitive case (8-year-old boy). During the treatment endogenous creatinine clearance and the amount of sodium excreted, as well as osmolar clearance increased, while free water clearance decreased. The site of action seems to be the distal portions of nephron, and water permeability of the area is enhanced by chlorpropamide, resembling the action of antidiuretic hormone. But the cellular mechanism of chlorpropamide action seems to be different from that of vasopressin. When taken proper care of hypoglycemia, chlorpropamide seems to be a drug of choice, making the frequent injection of vasopressin unnecessary.

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