All issues > Volume 11(2); 1968

Original Article

J Korean Pediatr Soc. 1968;11(2):57-64. Published online February 28, 1968.

The Follow-up Study of Tuberculin Tests after BCG Vaccination

Hyun Woo Kim¹

¹Department of Pediatrics, College of Medicine, Seoul National University

Abstract

Mantoux (1 tuberculin unit PPD) and patch (10t.u. PPD) tests were performed at the same time in 311 of BCG-vaccinated children under 7 years age group. 19 of them were multiple BCG-vaccinated orphans. Results of tests were analized and reactivities of each age group were compared to that of natural infection. Brief review of world literatures was involved in this article. 1)Positive rate of patch test peaked at 3 months after BCG vaccination. Thereafter it was gradually decreased to 76.5% at 3 years, and then was rapidly dropped to below 50% in 4~7 years. In multiple vaccinated group positive rate showed 83.3%. 2)Positive rate of Mantoux test was generally low in all age groups, but positive rate of multiple BCG-vaccinated group was relatively high (63.2%) while those of Mantoux test were very low in all age groups (39.8% in 3 months, 38.0% in 18 months, 39.5% in 2 years, 24.3% in 3 years, and 26.3% in 4~7 years). 3)Intermediate form of P.P.D. preparation(10 t.u.) was recommended for BCG-vaccinated children. 4)Strong reaction such as double redness, purplish discoloration, vesicle and crust formation, and necrosis were appeared very frequently in natural infection group (45.1%) which was 10 times as high as that of BCG-vaccinated group (4.5%). 5)Mean diameters of induration calculated as 8.3 mm. (土2.37 mm.) in 3 months, 10.7 mm. (+4.39 mm.) in 18 months, 14.3 mm. (+6.71 mm.) in 2 years, 11.9 mm. (土3.94 mm) in 3 years and 13.5 mm. (±2.12 mm.) in 4~7 years. These results were significantly low as compared to 16.6 mm. (土 3.99 mm,) in natural infection group except the value of 2 years. On statistical analysis these comparison were very significant in all age groups except 2 years group (t-values were less than 5%). In 2 years group strong reaction appeared 4 among 15 positive cases which chiefly influenced high reactivity. If these 4 babies supposed to receive natural infection previously mean diameter of induration decreased from 14.3 mm. (土6.71 mm.) to 11.2 mm.(±2.88 mm), which was also signicant statistically.

Keywords :