All issues > Volume 11(7); 1968

Original Article

J Korean Pediatr Soc. 1968;11(7):375-380. Published online July 31, 1968.

Juvenile Pernicious Anemia in Sisters

Hyun Lee¹, Goeng Pil Chun¹, Ki Yung Lee¹, Duk Jin Yun¹

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul，Korea

Abstract

Two cases of juvenile pernicious anemia in Korean sisters have been followed for 4 years since 7 years and 4 years of age respectively. The symptoms and signs were pale facies, general malaise, sore tongue, anorexia, frequent febrile episodes, macrocytic anemia, thrombocytopenia, multilobulated leu- cocytes with more than 6 lobules and megaloblastic proliferation in bone marrow aspiration. Dramatic hematological response to the parenteral administration of vitamin B12 with a significantly increased excretion rat Qof vitamin B12 by Schilling test as shown by an increase from 0 to 11.6% in elder sister and from 0 to 5.6% in younger sister with the addition of commercial intrinsic factor concentrate were demonstrated. These findings are compatible with the characteristics of juvenile pernicious anemia resulting from defect of Castle’s intrinsic factor.

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