All issues > Volume 7(2); 1964

Original Article

J Korean Pediatr Soc. 1964;7(2):6-32. Published online August 31, 1964.

The effects of ACTH or of “ Shockng Stress" on the gastric mucosa of Vitamin A deficient rats

YeungUn Mun¹

¹Department of Pediatrics,Yonsei University College of Medicine, Seoul, Korea

Abstract

1.The rats fed on vitamin A free diet for one month to three months did not produce gastric lesions. However, when the ACTH was administered, small superficial ulcers were demonstrated in the mucosa of the glandular stomach both in the study group and control group. The extent and incidence of gastric lesions were more pronounced in the study group. 2.Application of mechanical shaking caused gastric ulcers in the glandular portion of stomach and forestomach and it was more pronounced in the study group. The severity and incidence, of gastric lesion was parallel to the frequency and duration of the application of shaking stress. The response to the “shaking stress" was more pronounced among the young rats. 3.The urinary 17-ketosteroid excretion was increased when rapid acting ACTH or stronger shaking stress were applied in both study and control groups. However, the long acting ACTH gel or milder “shaking stress“ did not produce any remarkable change of urinary 17-ketetosteroid excretion. 4.Twenty-four hour uropepsin output increased four to five times among the study group after administration of rapid acting ACTH and two to three times after the application of mechanical shaking. 5.When ACTH was administered to the study group, 24 hours uropepsin output increased four to five times of that before the administration of ACTH. The application of "shaking stress" also caused two to three times more excretion than before the application of “shaking stress". The control group did not show any significant increase in uropepsin excretion with the administration of ACTH or application of "shaking stress". 6.The growth of study group began to decline about one month after the initiation of vitamin A free diet while the control group continued to grow. This was more marked among the young rats. The young rats bom of mother rat fed on vitamin A free diet showed remarkable decline of growth.

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