All issues > Volume 8(2); 1965

Case Report

J Korean Pediatr Soc. 1965;8(2):51-56. Published online May 31, 1965.

A Case of Letterer-Siwe Disease.

Kir Young Kim¹, Ki Young Lee¹, Kook Hoon Ko¹, Geukdong KO¹

¹Dept, of Pediatrics Yonsei Medical School

Abstract

This is a report of a 10 months-old male with Letterer-Siwe disease. The patient illustrated the classical clinical features of the disease, including maculopapular rash, hemorrhagic manifestations, anemia,diarrhea, marked enlargement of the spleen & liver, and susceptibility to secondary infection. Most of these signs developed soon after birth. (Fig. 1,2, & 3) Diagnosis was confirmed by microscopic examination, of skin biopsy and bone marrow aspiration. (Fig. 4 & 5) The patient received intensive antibiotic and corticosteroid therapy without improvement.

Keywords :