Clinical and Experimental Pediatrics

All issues > Volume 65(3); 2022

Rastad and Seifi Alan: Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis

Correspondence and Reply
Psychiatric/Psychology

Published online: February 17, 2022

DOI: https://doi.org/10.3345/cep.2021.01298.r1

Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis

Hadith Rastad¹, Mahnaz Seifi Alan²

¹Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

²Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran

Corresponding author: Mahnaz Seifi Alan Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Email: m_seifi2012@yahoo.com

Received August 22, 2021 Accepted October 28, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

See the reply "Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis" via https://doi.org/10.3345/cep.2021.01298.r2.

See the article "Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis" via https://doi.org/10.3345/cep.2021.00178.

To the editor: We read with great interest a meta-analysis by Maleki et al. [1] on the association between prenatal excess of androgen exposure in the offspring of mothers with polycystic ovary syndrome (PCOS) and risk of attention-deficit/hyperactivity disorder (ADHD) in them. They found that maternal PCOS increases the offspring risk of ADHD. However, we have to point out a deficiency of this study, we noted that 1 of 6 articles that were included in this study did not meet the eligibility criteria as it’s object was different [2]. Hergüner et al. [2] aimed to compare ADHD symptoms between women with PCOS and controls. This deficiency may introduce bias and lead to a false conclusion.

Footnotes

Conflicts of interest

No potential conflict of interest relevant to this article was reported.

Funding

This letter received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

References

1. Maleki A, Bashirian S, Soltanian AZ, Jenabi E, Farhadinasab A. Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis. Clin Exper Pediatr 2021;37:716–20.
[Article]

2. Hergüner S, Harmancı H, Toy H. Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int J Psychiatry Med 2015;50:317–25.
[Article] [PubMed]