| Changes in Somatostatin Immunoreactive Neurons in Rat Corebral Cortes after Systemic Kainic acid Administration |
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Myung Yeun Lee, Sa Jun Chung, Chang Il Ahn |
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Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea |
| 흰쥐에서 Kainic Acid로 유발된 경련이 Somatostatin함유 대뇌피질 신경세포에 미치는 영향 |
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이명연, 정사준, 안창일 |
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경희대학교 의과대학 소아과학교실 |
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| Abstract |
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This study was aimed to clarify the effects of systemic kainic acid(KA) administration(10mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats.
Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA.
Thirty-six rats were observed by using the free-floating immunohistochemical method (modified ABC method).
The results were as follows:
1) In the anterior and posterior cingulate cortex, somatostatin immunoreactive neurons were not observed in 2, 6, 10days after treatment of KA including control group except Cg 1 showing some somatostatin immunoreactive neurons in 10days and control groups.
2) In the insular cortex, somatostatin immunoreactive neurons also were not observed in any groups except AIV showing few somatostatin immunoreactive neurons in control group.
3) In the perirhinal cortex, few somatostatin immunoreactive neurons were observed in 2days and 6 days groups. In control group, a number of somatostatin immunoreactive neurons observed.
4) A strong decrease of somatostatin immunoreactive neurons were observed in the frontal, parietal, temporal and occipital cortex 2 days after treatment of KA. Initially decreased somatostatin immunoreactive neurons had recovered to control 10 days after treatment.
5) Distribution of the somatostatin immunoreactive neurons was observed marked difference according to the cortical areas.
Somatostatin immunoreactive neurons in isocortex were more increased in number than the allcotex by control study.
The changes in somatostatin immunoreactive neurons after systemic treament of KA were marked in 2 days and 6 days, but these had recovered to control 10 days after the treatment of KA. It suggested the normalization of the cerebral function 10 days after seizure.
According to the cerebral cortex, the different distribution of somatostatin immunoreactive neurons in number was observed. |
| Key Words:
Kainic acid, Convulsion, Somatostatin, cerebral cortex |
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