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"Most downloaded" Articles are from the articles published in 2020 during the last six months.
- Review Article
- Oncology
- Update on infantile hemangioma
(264 times)
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Hye Lim Jung
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Clin Exp Pediatr. 2021;64(11):559-572. Published online May 26, 2021
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· Infantile hemangiomas (IHs) are the most common benign vascular tumors, occurring in 5%–10% of infants.
· IHs are characteristically not present at birth but are usually diagnosed at 1–4 weeks of age, rapidly proliferate until 5 months of age, and then spontaneously involute.
· High-risk IHs (10%) require early treatment from 1 month of age.
· Oral propranolol, a nonselective beta-blocker, is the first-line treatment for IHs. |
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- Infection
- Updates on the coronavirus disease 2019 vaccine and consideration in children
(185 times)
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Hyun Mi Kang, Eun Hwa Choi, Yae-Jean Kim
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Clin Exp Pediatr. 2021;64(7):328-338. Published online June 21, 2021
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· The number of coronavirus disease 2019 cases has exponentially increased worldwide, and children ≤19 years old account for 11.0% of all confirmed cases.
· mRNA vaccines, BNT162b2 and mRNA-1273, and adenoviral vector vaccines, AZD1222 and Ad26.COV2.S, authorized for emergency use in the Emergency Use Listing of the World Health Organization are reviewed.
· Clinical trials of these vaccines have shown that they are safe and serious adverse reactions are rarely observed. |
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- Nutrition
- Components of human breast milk: from macronutrient to microbiome and microRNA
(169 times)
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Su Yeong Kim, Dae Yong Yi
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Clin Exp Pediatr. 2020;63(8):301-309. Published online March 23, 2020
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Human breast milk (HBM) is essential for the infant’s growth and development right after birth and is an irreplaceable source of nutrition for early human survival. Various infant formulas have many similarities to HBM in many components, but there is no perfect substitute for HBM. Recently, various breast milk components and their roles have been studied according to the development... |
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- Allergy
- Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis
(158 times)
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Hye Yung Yum, Eun Kyo Ha, Yoon Ho Shin, Man Yong Han
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Clin Exp Pediatr. 2021;64(8):373-383. Published online August 10, 2020
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Rhinitis is among the most common respiratory diseases in children. Nonallergic rhinitis, which involves nasal symptoms without evidence of systemic allergic inflammation or infection, is a heterogeneous entity with diverse manifestations and intensities. Nonallergic rhinitis accounts for 16%–89% of the chronic rhinitis cases, affecting 1%–50% (median 10%) of the total pediatric population. The clinical course of nonallergic rhinitis is generally... |
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- Food allergies and food-induced anaphylaxis: role of cofactors
(146 times)
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Meeyong shin
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Clin Exp Pediatr. 2021;64(8):393-399. Published online November 12, 2020
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Question: What are the roles of cofactors in food allergies and food-induced anaphylaxis?
Finding: Cofactors reportedly play a role in approximately 14%–30% of anaphylactic reactions. Cofactors such as exercise, infection, nonsteroidal anti-inflammatory drugs, dehydration, and alcohol can increase intestinal permeability and antigen uptake, thereby causing allergic symptoms.
Meaning: Routine assessment of the possible involvement of cofactors is essential for the management of patients with food-induced anaphylaxis. |
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- Other
- Comparison of diagnostic and treatment guidelines for undescended testis
(144 times)
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Jaeho Shin, Ga Won Jeon
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Clin Exp Pediatr. 2020;63(11):415-421. Published online March 23, 2020
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Primary caregivers should consider surgical specialist referral of patients with undescended testis if no descent occurs by 6 months, undescended testis is newly diagnosed after 6 months of age, or testicular torsion is suspected. Orchiopexy is recommended between 6 and 18 months at the latest. The original location of the testes and the age at orchiopexy are predictive factors for infertility and malignancy later in life. |
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- Critical Care Medicine
- Pediatric postintensive care syndrome: high burden and a gap in evaluation tools for limited-resource settings
(137 times)
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Chanapai Chaiyakulsil, Rapee Opasatian, Paweethida Tippayawong
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Clin Exp Pediatr. 2021;64(9):436-442. Published online December 18, 2020
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Pediatric postintensive care syndrome has high impact and burden and can affect a child’s life for decades. The early evaluation and detection of such problems require a simple and less time-consuming surveillance tool. Current evaluation tools can be difficult and strenuous for areas with limited resources. Thus, a new simple tool is required for the early detection and intervention of postintensive care syndrome in critically ill children |
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- Neurology
- Health effects of electromagnetic fields on children
(135 times)
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Jin-Hwa Moon
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Clin Exp Pediatr. 2020;63(11):422-428. Published online May 26, 2020
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· The nervous systems of children are more vulnerable to the effects of electromagnetic waves than adults.
· The exposure to electromagnetic fields (EMFs) among children should be minimized.
· According to International Agency for Research on Cancer EMFs are possibly carcinogenic, it should not be overlooked or interpreted with bias. |
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- Original Article
- General Pediatrics
- Risk factors for childhood pneumonia: a case-control study in a high prevalence area in Indonesia
(119 times)
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Vivi Ninda Sutriana, Mei Neni Sitaresmi, Abdul Wahab
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Clin Exp Pediatr. 2021;64(11):588-595. Published online March 15, 2021
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Question: Is the incidence of childhood pneumonia influenced by breastfeeding and basic immunization status?
Finding: Exclusive breastfeeding and complete basic immunization status have an effect in limiting the incidence of childhood pneumonia.
Meaning: While exclusive breastfeeding and complete basic immunization the Expanded Program on Immunization status are important factors for reducing the incidence of childhood pneumonia, indoor air pollution was also a significant risk factor. |
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- Review Article
- Nephrology (Genitourinary)
- Obesity and chronic kidney disease: prevalence, mechanism, and management
(119 times)
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Hyung Eun Yim, Kee Hwan Yoo
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Clin Exp Pediatr. 2021;64(10):511-518. Published online April 6, 2021
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· Obesity is strongly associated with the development and progression of chronic kidney disease.
· Altered renal hemodynamics, metabolic effects, and lipid nephrotoxicity may play a key role in the development of obesity-related kidney disease.
· Children born to obese mothers are at increased risk of developing obesity and chronic kidney disease later in life.
· A multilevel approach is needed to prevent obesity and related chronic diseases. |
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- Neurology
- Myelin oligodendrocyte glycoprotein antibody-associated disorders: clinical spectrum, diagnostic evaluation, and treatment options
(118 times)
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Yun-Jin Lee, Sang Ook Nam, Ara Ko, JuHyun Kong, Shin Yun Byun
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Clin Exp Pediatr. 2021;64(3):103-110. Published online May 14, 2020
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MOG antibody-associated disorder exhibits different pathophysiological and phenotypic findings than both aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder and typical MS. MOG-antibody is of particular interest in pediatric patients with clinical or radiological non-MS typical findings. MOG-antibody was included in a diagnostic algorithm for children recommending for the first time a standardized use in clinical practice except in cases of typical MS. |
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- Review Article
- Pulmonology
- Current perspectives on atypical pneumonia in children
(114 times)
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Jung Yeon Shim
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Clin Exp Pediatr. 2020;63(12):469-476. Published online June 10, 2020
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Macrolides are the first line treatment in atypical pneumonia caused by M. pneumoniae, C. pneumoniae, and L. pneumophila. Macrolide-resistant mycoplasma pneumonia (MRMP) is emerging worldwide, especially in East Asia. Immune modulators such as corticosteroids or second line antibiotics are treatment options for MRMP. Pediatricians should be careful with empirical therapy of macrolides in children with mild to moderate community-acquired pneumonia not to increase the risk of MRMP. |
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- Nutrition
- Dietary intake and nutritional status of Korean children and adolescents: a review of national survey data
(112 times)
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Minji Kang, So Yoon Choi, Minyoung Jung
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Clin Exp Pediatr. 2021;64(9):443-458. Published online December 28, 2020
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In Korea, several national cross-sectional surveys monitor the diet, nutritional status, and health status of children. This continual dedicated national surveillance system contributes to the identification of nutritional and health issues, establishment of public health policies, and development of nutrition recommendations. This paper provides recent information about the Korea National Health and Nutrition Examination Survey and the Korean Youth Risk... |
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- Allergy
- Montelukast use over the past 20 years: monitoring of its effects and safety issues
(111 times)
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Yong Ju Lee, Chang-Keun Kim
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Clin Exp Pediatr. 2020;63(10):376-381. Published online February 5, 2020
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Although the efficacy of montelukast is inferior to that of ICS, both physicians and parents prefer montelukast to ICSs.
EDN may be a useful biomarker for the treatment and monitoring of preschool children with asthma.
The US FDA requires boxed warning about serious neuropsychiatric events of montelukast, therefore, physicians should consider the benefits and risks of montelukast before prescribing it. |
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- Neurology
- Is it really a seizure? The challenge of paroxysmal nonepileptic events in young infants
(110 times)
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Seung Yeon Jung, Joon Won Kang
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Clin Exp Pediatr. 2021;64(8):384-392. Published online September 18, 2020
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Paroxysmal nonepileptic events (PNE) comprise of a variety of nonepileptic behaviors and are divided into various types. A more accurate diagnosis is possible by examining the video clip provided by the caregiver. In infants, physiologic PNE accounts for the majority of the PNE. It is important to exclude epilepsy, for which blood tests, electroencephalography, and imaging tests can facilitate differential... |
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- Pulmonology
- High-flow nasal cannula oxygen therapy in children: a clinical review
(106 times)
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Ji-Won Kwon
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Clin Exp Pediatr. 2020;63(1):3-7. Published online October 28, 2019
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High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm... |
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- Original Article
- Infection
- Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city
(104 times)
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Mi Ae Chu, Yoon Young Jang, Dong Won Lee, Sung Hoon Kim, Namhee Ryoo, Sunggyun Park, Jae Hee Lee, Hai Lee Chung
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Clin Exp Pediatr. 2021;64(12):652-660. Published online October 12, 2021
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Question: What is the natural course of viral load in children with coronavirus disease 2019 (COVID-19)?
Finding: A significant number of patients still had a relatively high viral load once clinically asymptomatic. Nearly half of the patients experienced viral rebound, which contributed to prolonged viral detection in their respiratory specimens.
Meaning: Further studies are needed to determine the clinical significance of viral rebound in asymptomatic or mild pediatric cases of COVID-19. |
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- Review Article
- Hematology
- Thrombosis and severe acute respiratory syndrome coronavirus 2 vaccines: vaccine-induced immune thrombotic thrombocytopenia
(103 times)
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Young Shil Park
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Clin Exp Pediatr. 2021;64(8):400-405. Published online June 30, 2021
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· Thrombosis and thrombocytopenia occurring within 4–28 days after severe acute respiratory syndrome coronavirus 2 vaccination require attention.
· The terms vaccine-induced immune thrombotic thrombocytopenia (VITT) and thrombosis with thrombocytopenia syndrome (TTS) are used.
· VITT is pathogenetically similar to heparin-induced thrombocytopenia.
· VITT/TTS could be associated with the development of platelet-activating anti-platelet factor 4 antibodies.
· For suspected VITT/TTS, early treatment decisions (intravenous immunoglobulin, non-heparin anticoagulant, and avoidance of platelet transfusions) are important. |
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