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"Most downloaded" Articles are from the articles published in 2022 during the last six months.
- Review Article
- Neurology
- Promising candidate cerebrospinal fluid biomarkers of seizure disorder, infection, inflammation, tumor, and traumatic brain injury in pediatric patients (18 times)
- Seh Hyun Kim, Soo Ahn Chae
- Clin Exp Pediatr. 2022;65(2):56-64. Published online August 23, 2021
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· Pediatric cerebrospinal fluid (CSF) components have been extensively evaluated as biomarkers of various neurologic diseases.
· Several promising candidate CSF biomarkers, including Tau, glial fibrillary acidic protein, neuron-specific enolase, S100β, and interleukins, have been studied in pediatric patients with seizure disorders, central nervous system infections, inflammation, tumors, hypoxic-ischemic encephalopathy, traumatic brain injuries, intraventricular hemorrhage, and congenital hydrocephalus.
· Circulating microRNAs in the CSF are a promising class of biomarkers for various neurological diseases.
- Infection
- Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea (18 times)
- Byung Ok Kwak, Young Jin Hong, Dong Hyun Kim
- Clin Exp Pediatr. 2022;65(3):108-114. Published online September 24, 2021
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Since the introduction of a universal Japanese encephalitis (JE) vaccination program and urbanization, the incidence of JE has dramatically decreased in Korea. However, recent JE cases have occurred, predominantly among unvaccinated adults and with a shift in age distribution. Continuous surveillance of the seroprevalence of JE is required to establish a proper immunization policy in Korea.
- Original Article
- General Pediatrics
- Effect of 2–6 weeks of systemic steroids on bone mineral density in children (18 times)
- Athira Kuniyil, Somdipa Pal, Namrita Sachdev, Tribhuvan Pal Yadav
- Clin Exp Pediatr. 2022;65(5):254-261. Published online November 18, 2021
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Question: Does steroid use for 2–6 weeks in children affect bone mineral content (BMC) or density (BMD)?
Finding: Steroid use for 2–6 weeks significantly decreased BMC and BMD of the whole body, total body less the head, lumbar spine, and distal radius. A significant negative correlation was observed among BMD, duration, and cumulative dose.
Meaning: Steroid use for 2–6 weeks in children negatively affected BMC and BMD.
- Review Article
- Neonatology (Perinatology)
- Breastfeeding and vitamin D (18 times)
- Ju Sun Heo, Young Min Ahn, Ai-Rhan Ellen Kim, Son Moon Shin; for the Korean Society of Breastfeeding Medicine
- Clin Exp Pediatr. 2022;65(9):418-429. Published online December 14, 2021
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∙ Exclusively breastfed infants are at risk of developing vitamin D deficiency associated with hypocalcemia, rickets, and various health outcomes.
∙ The prevalence of vitamin D deficiency in breastfed infants differs vastly between studies and nations at 0.6%–91.1%.
∙ The vitamin D content of breast milk does not meet the requirements of exclusively breastfed infants.
∙ Most international guidelines recommend that breastfed infants be supplemented with 400 IU/day of vitamin D during the first year of life.
∙ Vitamin D intake (milk+supplements) of 800 IU/day can be considered in preterm infants along with biochemical monitoring.
- Editorial
- Endocrinology
- Pediatric obesity: life cycle approach of pediatrician and society (18 times)
- Yong Hee Hong
- Clin Exp Pediatr. 2022;65(1):29-30. Published online December 28, 2021
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• With the emerging epidemic of pediatric obesity, many endocrine comorbidities classically seen in adulthood are surfacing much earlier in life.
• Appropriate obesity counseling and education should be provided from infancy to adolescence.
• Managing pediatric obesity may require school and society involvement.
- Original Article
- Developmental and Behavioral Medicine
- Parenting stress and interactive engagement behaviors in children with developmental delay (18 times)
- Jung Sook Yeom, Rock Bum Kim, Jae Young Cho, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo
- Clin Exp Pediatr. 2023;66(6):252-261. Published online May 19, 2023
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· Question: What level of parenting stress is experienced by parents of children with developmental delays (DDs) without autism spectrum disorder, and what factors contribute to it?
· Findings: Parents of children with DDs experienced high parenting stress that were significantly mediated by their children’s low interactive behaviors.
· Meaning: The interactive behaviors of children with DDs mediate parenting stress.
- Attention-deficit/hyperactive-impulsive disorder symptoms among grade 1 students with reading disorder in Thailand (18 times)
- Patcharapun Sarisuta, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho
- Clin Exp Pediatr. 2023;66(11):485-492. Published online October 24, 2023
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Question: Would students with reading disorder have a significantly higher prevalence of attention-deficit/hyperactiveimpulsive disorder (ADHD) symptoms than neurotypical students?
Finding: Students at risk of reading disorder exhibited significant ADHD symptoms compared with those not at risk of reading disorder according to all presentations of teacher assessments versus only for predominantly inattentive presentations of the parental assessments.
Meaning: Students with reading disorder have a significantly higher prevalence of ADHD symptoms than neurotypical students. Sex, parental education level, average family income, and children’s school affiliation significantly influenced reading disorder prevalence.
- Pulmonology
- Modified high-flow nasal cannula for children with respiratory distress (17 times)
- Sarocha Itdhiamornkulchai, Aroonwan Preutthipan, Jarin Vaewpanich, Nattachai Anantasit
- Clin Exp Pediatr. 2022;65(3):136-141. Published online May 24, 2021
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Question: Can the modified high-flow nasal cannula (HFNC) provide alternative respiratory support for children with acute respiratory distress?
Finding: A total of 74 patients were assigned to the modified or commercial HFNC groups. The intubation rate, length of hospital stay, and adverse events did not differ between the 2 groups.
Meaning: The modified HFNC can provide alternative respiratory support for pediatric respiratory distress.
- Review Article
- Infection
- Four months of rifampicin monotherapy for latent tuberculosis infection in children (17 times)
- Chi Eun Oh, Dick Menzies
- Clin Exp Pediatr. 2022;65(5):214-221. Published online October 29, 2021
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· Recently, the importance of a short-term treatment regimen including rifamycin has been highlighted in the treatment of latent tuberculosis infection (LTBI).
· Four prospective or retrospective studies in children consistently reported that a 4-month daily rifampicin regimen (4R) had a higher completion rate than and comparable safety to a nine-month daily isoniazid regimen.
· We suggest rifampicin 20–30 mg/kg/day for children aged 0–2 years and 15–20 mg/kg/day for children aged 2–10 years in 4R to treat LTBI.
- Cardiology
- Implication of microRNA as a potential biomarker of myocarditis (17 times)
- Jin-Hee Oh, Gi Beom Kim, Heeyoung Seok
- Clin Exp Pediatr. 2022;65(5):230-238. Published online March 2, 2022
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· Myocarditis was recently examined quantitatively as inflammation of the heart muscle based on endomyocardial biopsy, and its noninvasive diagnosis remains unsatisfactory.
· Additionally, numerous miRNAs (miR-155, miR-146b, miR-590, miR-221, miR-222, etc.) coupled with inflammation or viral activation have been examined in myocarditis patients or mouse models.
· The recent identification of mmu-miR-721 (has-miR-Chr8: 96), a myocarditis-specific microRNA, demonstrated its potential as an acute myocarditis biomarker.
- Editorial
- Cardiology
- Characteristics of z score systems for diagnosing coronary abnormalities in Kawasaki disease (17 times)
- Gyeong-Hee Yoo
- Clin Exp Pediatr. 2022;65(9):448-449. Published online March 14, 2022
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Because of the various body sizes of children with Kawasaki disease (KD), coronary artery diameter requires normalization to the body surface area as a z score.
In updated guidelines, coronary artery abnormalities are important criteria in the diagnosis of KD, and z score systems have been accepted to define coronary artery abnormalities.
However, the z score formula should be selected carefully because each yields different results.
- Original Article
- Oncology
- Treatment outcomes of high-dose chemotherapy plus stem cell rescue in high-risk neuroblastoma patients in Thailand (17 times)
- Kunanya Suwannaying, Piti Techavichit, Patcharee Komvilaisak, Napat Laoaroon, Nattee Narkbunnam, Kleebsabai Sanpakit, Kanhatai Chiengthong, Thirachit Chotsampancharoen, Lalita Sathitsamitphong, Chalongpon Santong, Panya Seksarn, Suradej Hongeng, Surapon Wiangnon
- Clin Exp Pediatr. 2022;65(9):453-458. Published online May 24, 2022
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Question: This study aimed to elucidate the outcomes of high-risk neuroblastoma (HR-NB) patients treated with high-dose chemotherapy and stem cell rescue without immunotherapy.
Finding: The 5-year overall survival and event-free survival rates were 45.1% and 40.4%, respectively.
Meaning: High-dose chemotherapy plus stem cell rescue followed by cis-retinoic acid for 12 months is well tolerated and could improve survival in patients with HR-NB in limited resource settings.
- Review Article
- Other
- Epidemiology of pediatric fractures before versus during the coronavirus disease 2019 pandemic (17 times)
- Chi Hoon Oh, Siyeong Yoon, Kyung Rae Ko, Young Woo Kwon, Kyeong Mi Kim, Hyun Seo Park, Hogyeong Kang, Inseok Jang, Soonchul Lee
- Clin Exp Pediatr. 2022;65(7):330-336. Published online June 3, 2022
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∙ The novel coronavirus disease 2019 (COVID-19) was first reported in December 2019 as a cluster outbreak in Wuhan, since then, national lockdowns have included school closures, stay-at-home orders.
∙ The characteristics of adolescent fractures were often related to physical activity such as sports-related injury.
∙ During the COVID-19 pandemic, both in the East and the West, the incidence of fractures in children and adolescents is showing a decreasing trend worldwide.
∙ Fractures in children and adolescents were significantly reduced in the proportion of relatively low-energy damage, and the incidence of fractures in adolescents with greater activity compared to children was reduced.
∙ If COVID-19 pandemic ends, normal academic and sports activities increase due to the easing of lockdown policies, the number of trauma patients related to increased activity may increase rapidly, and clinics should prepare for this change.
- Original Article
- Nutrition
- Not breastfeeding and risk of autism spectrum disorders among children: a meta-analysis (17 times)
- Ensiyeh Jenabi, Saeid Bashirian, Amir Mohammad Salehi, Salman Khazaei
- Clin Exp Pediatr. 2023;66(1):28-31. Published online July 19, 2022
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This study aimed to determine whether there is an association between not breastfeeding (versus breastfeeding) and the risk of autism spectrum disorders (ASD) among children. We found that the risk of ASD associated with not breastfeeding had an odds ratio of 1.81 (95% confidence interval, 1.35–2.27; I2=0 %). These findings suggest the importance of breastfeeding in decreasing the risk of ASD among children.
- Letter to the Editor
- Neonatology (Perinatology)
- Assessment of iron status and red cell parameters in healthy term small for gestational age neonates at birth (17 times)
- Arif Hossain, Shorna Rahman, Shahana Akter, Ismat Jahan, Sanjoy Kumer Dey, Abdul Mannan, Mohammod Shahidullah
- Clin Exp Pediatr. 2024;67(4):221-223. Published online March 19, 2024
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- Clinical Note
- Genetics and Metabolism
- Biallelic POLR3A variants cause Wiedemann-Rautenstrauch syndrome with atypical brain involvement (16 times)
- Byungseung Moon, Minhye Kim, Hye Jin Kim, Jae So Cho, Hey Joon Son, Byung Chan Lim, Ki Joong Kim, Jong Hee Chae, Soo Yeon Kim
- Clin Exp Pediatr. 2023;66(3):142-144. Published online December 30, 2022
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- Editorial
- Gastroenterology
- Recent advances in epigenetic mechanisms, diagnosis, and treatment of pediatric gastrointestinal allergic disorders (16 times)
- Eell Ryoo
- Clin Exp Pediatr. 2023;66(6):250-251. Published online May 19, 2023
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· Epigenetic mechanisms are involved in rapidly increasing food allergy.
· There is still no definitive way to diagnose food allergy.
· Early introduction of peanuts, eggs, and cow’s milk reduces food allergy incidence.
· Administration of probiotics such as Lactobacillus rhamnosus GG, Bifidobacterium bifidum can partially reduce the occurrence of allergic symptoms.
- Review Article
- Infection
- Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease (15 times)
- Jung-Woo Rhim, Jin-Han Kang, Kyung-Yil Lee
- Clin Exp Pediatr. 2022;65(4):153-166. Published online November 23, 2021
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· Severe cases of coronavirus disease, Kawasaki disease (KD), and multisystem inflammatory syndrome in children (MIS-C) share similar findings: a protracted clinical course, multiorgan involvement, and similar activated biomarkers.
· Here we propose etiological agents in KD and MIS-C as species in the microbiota and introduce a common pathogenesis through the protein-homeostasis-system hypothesis.
· Early proper dose of corticosteroids and/or intravenous immunoglobulin may help to reduce morbidity and mortality in these diseases.
- General Pediatrics
- Motor performance of children with attention deficit hyperactivity disorder: focus on the Bruininks-Oseretsky Test of Motor Proficiency (15 times)
- Khushboo Prashant Adhvaryu, Suruliraj Karthikbabu, Pratiksha Tilak Rao
- Clin Exp Pediatr. 2022;65(11):512-520. Published online February 17, 2022
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· Children with attention deficit hyperactivity disorder (ADHD) tend to have impaired motor performance that may affect their growth and development.
· Although widely used among children with developmental disorders, the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) is used sparsely among children with ADHD.
· Assessment by the BOTMP increases our understanding of the motor repertoire of children with ADHD.
· Wider usage of the BOTMP will enable more comprehensive planning of rehabilitation goals to enhance the motor abilities of children with ADHD.
- Editorial
- Neurology
- Increasing our understanding of rotavirus-induced central nervous system manifestations (15 times)
- Jon Soo Kim
- Clin Exp Pediatr. 2022;65(11):536-537. Published online May 6, 2022
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· Diverse clinicoradiological features of central nervous system (CNS) complications in rotavirus infection can be identified with the rapid and wide use of various brain magnetic resonance imaging protocols.
· An increased understanding of the various pathophysiological mechanisms of rotavirus-induced CNS manifestations will enable precise management in the future.
- Letter to the Editor
- Allergy
- Increased serum eosinophilic cationic protein in children with nonspecific chronic cough (15 times)
- Young Hwan Kim, Yoon Young Jang, Jieun Jeong, Hai Lee Chung
- Clin Exp Pediatr. 2023;66(10):455-457. Published online September 14, 2023
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- Review Article
- Neurology
- Recent trends of healthcare information and communication technologies in pediatrics: a systematic review (14 times)
- Se young Jung, Keehyuck Lee, Hee Hwang
- Clin Exp Pediatr. 2022;65(6):291-299. Published online December 15, 2021
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· The innovation of healthcare information communication technology (ICT) was accelerated with the adoption of electronic health records (EHRs).
· Telemedicine currently has no technical barriers.
· EHRs and personal health records are being connected, and mobile/wearable technologies are being integrated into them.
· Conventional rule-based clinical decision support systems have already been implemented and used in EHRs and PHRs. Artificial intelligence/machine learning improves precision and accuracy.
- Original Article
- Hematology
- Effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major: a single-center study (14 times)
- Mahmoud A. El-Hawy, Nagwan Y. Saleh
- Clin Exp Pediatr. 2022;65(8):405-409. Published online June 7, 2022
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Question: What is the effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major?
Finding: The dual-energy x-ray absorptiometry scan findings of children with β-thalassemia major and osteoporosis were improved after pamidronate administration.
Meaning: Cyclic pamidronate effectively treated osteoporosis in children with β-thalassemia major.
- Clinical Note
- Rheumatology
- Haploinsufficiency A20 misdiagnosed as PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome with Kikuchi disease (14 times)
- Kyo Jin Jo, Su Eun Park, Chong Kun Cheon, Seung Hwan Oh, Seong Heon Kim
- Clin Exp Pediatr. 2023;66(2):82-84. Published online June 22, 2022
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- Editorial
- Pulmonology
- Now lung ultrasound has been established as a fundamental examination in pediatric respiratory diseases (14 times)
- Kyunghoon Kim
- Clin Exp Pediatr. 2022;65(8):401-402. Published online July 13, 2022
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· Several studies demonstrated the usefulness of lung ultrasound in pediatric respiratory diseases including coronavirus disease 2019.
· Knowledge of lung ultrasound is increasing, and lung ultrasound has been established as a fundamental diagnostic examination for pediatric respiratory diseases.
- Letter to the Editor
- Infection
- Chest x-ray findings in children with COVID-19: lesson learned from referral hospitals in Medan, North Sumatera, Indonesia (14 times)
- Andrew Limavady, Eka Airlangga, Ririe Fachrina Malisie, Ayodhia Pitaloka Pasaribu
- Clin Exp Pediatr. 2023;66(7):317-319. Published online May 16, 2023
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- Editorial
- Neurology
- Lumbar puncture or not: when does febrile seizure require a neurodiagnostic evaluation? (14 times)
- Seung Soo Kim
- Clin Exp Pediatr. 2023;66(2):68-69. Published online December 9, 2022
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· A neurodiagnostic evaluation (lumbar puncture, blood tests, electroencephalography, and neuroimaging) is not indicated in most patients with simple febrile seizures.
· A lumbar puncture is indicated when a central nervous system infection is suspected in any patient with febrile seizures.
· Blood tests (glucose, electrolytes, and complete blood count) are indicated in patients with persistent seizure after benzodiazepine treatment, prolonged loss of consciousness, poor general condition, or signs of dehydration.
- Original Article
- Infection
- Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature (14 times)
- Abdulrasheed Usman, Muhammad Hamis Musa, Bukhari Isah Shuaib, Olayemi Balogun, Mukhtar Adeiza
- Clin Exp Pediatr. 2023;66(7):307-316. Published online December 22, 2022
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The peripartum period is an important transmission time for human T-cell lymphotropic virus-1 (HTLV-1) infection, mainly via breastfeeding and partly through the placental tissues of carrier mothers. Although most HTLV-1–infected individuals are asymptomatic, fetal and childhood infections often result in several diseases with disappointing treatment outcomes. An estimated HTLV-1 burden in Nigeria among perinatal women must be determined to enable rational planning of a comprehensive health care intervention.
- Endocrinology
- Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis (13 times)
- Azam Maleki, Saeid Bashirian, Ali Reza Soltanian, Ensiyeh Jenabi, Abdollah Farhadinasab
- Clin Exp Pediatr. 2022;65(2):85-89. Published online April 15, 2021
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Question: Have polycystic ovary syndrome (PCOS) increased risk of having an offspring with attention-deficit/hyperactivity disorder (ADHD)?
Finding: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on odds ratio (OR) and relative ratio (RR) (OR, 1.42; 95% confidence interval [CI], 1.27–1.57) and (RR, 1.43; 95% CI, 1.35–1.51), respectively.
Meaning: Our study showed that maternal PCOS is a risk factor for ADHD.
- Review Article
- Other
- Knowledge-guided artificial intelligence technologies for decoding complex multiomics interactions in cells (13 times)
- Dohoon Lee, Sun Kim
- Clin Exp Pediatr. 2022;65(5):239-249. Published online November 26, 2021
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· The need for data-driven modeling of multiomics interactions was recently highlighted.
· Many artificial intelligence-driven models have been developed, but only a few have incorporated biological domain knowledge within model architectures or training procedures.
· Here we provide a comprehensive review of deep learning models to decipher complex multiomics interactions regarding the biological guidance imposed upon them to facilitate further development of biological knowledge-guided deep learning models.
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
