Most downloaded
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most downloaded
"Most downloaded" Articles are from the articles published in 2024 during the last six months.
- Original Article
- Other
- Did government subsidy program improve quality of care for children with complex chronic conditions in children’s hospitals? A quasi-experimental study in South Korea
(35 times)
-
Riyoung Na, Myoung-Hee Kim, Seok-Jun Yoon
-
Clin Exp Pediatr. 2026;69(7):582-592. Published online May 28, 2026
-
|
Question: Do government-funded Specialized Public Medical Centers for Children (SPMCCs) improve the quality of care for pediatric patients requiring complex and intensive medical care?
Finding: The SPMCC hospital designation reduced 30-day readmission rates among pediatric patients with severe conditions.
Meaning: Government investments are associated with improved quality of care for children with complex chronic conditions. Therefore, sustained government funding is essential to enhancing pediatric care quality. |
-
-
- Association between sodium content of intravenous immunoglobulin and electrolyte changes and clinical course of Kawasaki disease
(35 times)
-
Yoshitaka Watanabe, Naomi Yagi, Toya Hattori, Chisato Oyake, Shota Endo, Maria Yoshimi, Takayoshi Kyoda, Hirokazu Ikeda
-
Clin Exp Pediatr. 2026;69(8):639-645. Published online July 1, 2026
-
|
Question: Hyponatremia in Kawasaki disease is associated with inflammation and disease severity. Intravenous immunoglobulin (IVIG) formulations feature various sodium contents. What is the clinical impact of such variations?
Finding: IVIG sodium content was associated with sodium, potassium, and protein level changes.
Meaning: Coronary outcomes were similar but electrolyte changes differed: high-sodium IVIG caused hypokalemia, whereas low-sodium IVIG caused hyponatremia. IVIG preparation requires consideration when interpreting laboratory values. |
-
-
- Neurology
- Evaluation of pediatric migraine triggers: a single-center study
(34 times)
-
Hey-Joon Son, Joo-Ok Jin, Kon-Hee Lee
-
Clin Exp Pediatr. 2025;68(2):163-169. Published online November 11, 2024
-
|
Question: What are the primary triggers for pediatric migraines, and how do they impact clinical management?
Finding: Common triggers for pediatric migraines include sleep disturbances, academic stress, and motion sickness, with academic stress identified as the most intense.
Meaning: Recognizing and addressing specific triggers like sleep disturbance and academic stress is crucial to effectively managing pediatric migraines with emphasis on personalized care to improve outcomes. |
-
-
- Review Article
- Nutrition
- Exploring nutritional screening tools for hospitalized children: a narrative review
(34 times)
-
Pankaj Soni, Amit Agrawal, Gaurav Jadon
-
Clin Exp Pediatr. 2025;68(12):963-970. Published online October 22, 2025
-
|
Malnutrition is frequently identified in hospitalized children, and the use of nutritional screening tools is crucial for assessing their nutritional status during their hospital admission and stay. Common tools include the Pediatric Yorkhill Malnutrition Score, Screening Tool for Assessment of Malnutrition in Pediatrics, and Screening Tool for Risk of Nutritional Status and Growth. However, these tools have varying sensitivities and specificities, and none is recommended for all hospitalized children. |
-
-
- Original Article
- General Pediatrics
- Global and regional burden of neonatal disorders (preterm birth, encephalopathy, jaundice, and sepsis), 1990–2021 and projections to 2050
(34 times)
-
Yuseon Kang, Jeongseon Oh, Dongjin Yeo, Jaeyu Park, Sooji Lee, Na Yun Kim, Jungmin Park, Seung Ha Hwang, Tae Hyeong Kim, Dong Keon Yon
-
Clin Exp Pediatr. 2026;69(2):171-181. Published online October 30, 2025
-
|
This study provides the first comprehensive estimated global burden of neonatal disorders attributable to risk factors in 1990–2021 stratified by sex, cause, sociodemographic index (SDI), and region. We identified persistent disparities across SDI levels, with low birthweight and short gestation contributing most to the age-standardized disability-adjusted life year rate of neonatal disorders. These findings highlight the urgent need for targeted context-specific interventions to reduce infant mortality and improve neonatal health equity. |
-
-
- Gastroenterology
- Gut microbiota and metabolomic alterations in newborns of mothers with gestational diabetes mellitus
(34 times)
-
Wan-Hsin Su, Yi-Wei Wang, Chien-Chang Chen, Ming-Wei Lai, Hsun-Chin Chao, Ming-Chou Chiang, Ren-Huei Fu, Pai-Jui Yeh
-
Clin Exp Pediatr. 2026;69(1):26-35. Published online October 22, 2025
-
|
Question: Does maternal gestational diabetes mellitus (GDM) affect newborn gut microbiota and metabolomic profiles?
Finding: Neonates born to mothers with diet-controlled GDM exhibited reduced gut microbiota α-diversity, altered β-diversity, and metabolic shifts, including changes in fumarate and succinate levels, with peroxisome proliferator-activated receptor and adipocytokine signaling pathway activation.
Meaning: Maternal GDM affects early microbial colonization and metabolism in newborns and may have long-term health implications. |
-
-
- Editorial
- Neurology
- Limited improvement in outcomes of infantile epileptic spasms syndrome despite therapeutic advances
(34 times)
-
Donghwa Yang
-
Clin Exp Pediatr. 2026;69(5):384-385. Published online April 28, 2026
-
|
|
· Despite advances in treatment, infantile epileptic spasms syndrome remains associated with poor long-term epilepsy and developmental outcomes.
· Improved seizure control alone may not be sufficient, underscoring the need for early diagnosis and etiology-driven management strategies. |
-
-
- Review Article
- Allergy
- Action-plan and as-needed therapy in allergic rhinitis
(33 times)
-
Hyeon-Jong Yang
-
Clin Exp Pediatr. 2024;67(6):267-273. Published online May 21, 2024
-
|
· The guidelines may not work in the real world.
· An action-plan reflecting patient’s severity and variable of symptoms, values and preferences as well as the benefits and harms of treatment, may be a useful alternative.
· The action plan and as-needed therapy must include the following elements: when, what, how, and why.
· Action plan and as-needed therapy can help patients manage their symptoms more effectively. |
-
-
- Original Article
- Allergy
- Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study
(33 times)
-
Ami Uematsu, Masatsugu Orui, Mami Ishikuro, Keiko Murakami, Aoi Noda, Genki Shinoda, Taku Obara, Shinichi Kuriyama
-
Clin Exp Pediatr. 2026;69(1):36-45. Published online October 22, 2025
-
|
Question: Associations have been made between maternal sleep disorders during pregnancy and allergic diseases including bronchial asthma, atopic dermatitis, food allergy, and allergic conjunctivitis/rhinitis/hay fever in their children.
Finding: In the crude model, sleep disorders during pregnancy were associated with all examined allergic diseases in children. After adjustment, significant associations remained for atopic dermatitis and allergic conjunctivitis/rhinitis/hay fever.
Meaning: The study highlights associations between maternal sleep and child allergic diseases. |
-
-
- Editorial
- Pulmonology
- Telomere biology disorders in childhood interstitial lung disease: new insights from the chILD-EU cohort
(33 times)
-
Andrew Courtwright
-
Clin Exp Pediatr. 2026;69(7):542-544. Published online June 30, 2026
-
|
|
Greiner-Mai et al. expand recognition of telomere biology disorder (TBD)-associated interstitial lung disease (ILD) in children, demonstrating heterogenous radiographic and ILD subtypes in combination with variable extrapulmonary phenotypes, even in the absence of ultrashort peripheral blood telomere length (TL). While their findings highlight some of the limitations of current TL testing methods, they introduce critical questions regarding family screening and the role of antifibrotic and telomere-directed therapies in children with TBD-related ILD. |
-
-
- Allergy
- Comorbidities of allergic rhinitis in children
(32 times)
-
Yong Ju Lee
-
Clin Exp Pediatr. 2024;67(12):675-676. Published online July 31, 2024
-
|
· Allergic rhinitis in children often goes undiagnosed or untreated, with significant systemic complications like sleep disorders, growth issues, and gastrointestinal symptoms linked to nasal obstruction.
· A patient-centered action plan that considers symptom severity, preferences, and comprehensive management of associated complications is essential for effective treatment. |
-
-
- Review Article
- Gastroenterology
- Anxiety disorders presenting as gastrointestinal symptoms in children – a scoping review
(32 times)
-
Anjali Kumar, Pramodh Vallabhaneni
-
Clin Exp Pediatr. 2025;68(5):344-351. Published online January 13, 2025
-
|
A positive bidirectional relationship between gastrointestinal disorders and anxiety, but with no clear aetiology, was identified. Factors such as somatisation and pain catastrophising resulted in poorer pain-related outcomes in children. Further studies are required to understand this relationship in order to have targeted treatments and ensure better long term outcomes. |
-
-
- Nutrition
- The Korea Infant Physical Growth Examination Survey (KIPGroS): a study protocol
(32 times)
-
Jong Woo Hahn, MinSoo Shin, Jin Gyu Lim, Yoon-Joo Kim, Ki Soo Kang, Narae Lee, Seong Hee Jeong, Mun Hui Jeong, Yeoun Joo Lee, Eui Kyung Choi, Jung Ok Shim, Jee Yoon Park, Chan-Wook Park, Joo Young Kim, Su Jin Jeong, Young Hwa Jung, Jaehyun Kim, Chang Won Choi, Ju Whi Kim, Seung Han Shin, Yun Jeong Lee, Young Ah Lee, Choong-Ho Shin, Seung-sik Hwang, Young Eun Kim, Youn Ha Kang, Kyungwon Oh, Sungha Yun, Jae Sung Ko, Jin Soo Moon
-
Clin Exp Pediatr. 2025;68(5):352-358. Published online February 13, 2025
-
|
|
The suitability of World Health Organization (WHO) growth charts for assessing the growth of children under 3 years of age in all countries remains controversial, and their applicability must be evaluated based on country-specific growth data. The Korea Infant Physical Growth Examination Survey evaluated the suitability of WHO growth charts to contribute to the next revision of growth charts in Korea. |
-
-
- Review Article
- Endocrinology
- Lifelong medical challenges and immunogenetics of Turner syndrome
(31 times)
-
Won Kyoung Cho
-
Clin Exp Pediatr. 2024;67(11):560-568. Published online July 31, 2024
-
|
|
· This summary emphasizes the importance of the early diagnosis of Turner syndrome (TS) and presents a multidisciplinary approach to its prevention and management, high-lighting the need for customized care.
· Advancements in immunogenetic research may improve our understanding of TS and improve its outcomes.
· TS encompasses a wide array of medical challenges, including cardiovascular, endocrine, autoimmune, and mental health issues, as well as a heightened cancer risk. |
-
-
- Original Article
- General Pediatrics
- Lipoprotein(a) prevalence trends in Portuguese children and adolescents: a real-world perspective
(31 times)
-
Isabel Morais Ribeiro, Susete Vieira, Miguel Saraiva, Mónica Tavares, José Carlos Oliveira, Isabel Mangas Palma, Helena Ferreira Mansilha
-
Clin Exp Pediatr. 2025;68(12):1031-1040. Published online November 24, 2025
-
|
Early lipid screening, including lipoprotein(a) (Lp(a)), in children/adolescents is key to identifying and managing dyslipidemia and reducing the risk of early-onset cardiovascular disease. This study shows that prevalence of elevated Lp(a) in high-risk Portuguese children is alarming, with over 30% at intermediate/high risk and nearly 1% at very high-risk (>430 nmol/L). Since Lp(a) is mostly genetically determined, one-time early screening in atrisk children is crucial for timely monitoring and prevention. |
-
-
- Other
- Improvements in obesity-related measures among Asian patients with severe obesity following a structured lifestyle intervention
(31 times)
-
Pei-Shan Chen, Shu-Mei Tsai, Chih-Hsuan Chang, Hui-Ru Yang, Yen-Ju Huang, Hsiang-Yin Liu, Kai-Chi Chang, Huey-Ling Chen
-
Clin Exp Pediatr. 2026;69(3):247-256. Published online December 22, 2025
-
|
Question: How does obesity severity affect baseline fitness and improvements in key obesity-related measures following participation in a structured lifestyle modification program?
Finding: Severely obese youth showed poorer baseline physical fitness but greater improvements in key obesity-related measures following lifestyle interventions.
Meaning: Early targeted intervention may help prevent progression to more severe obesity and declines in physical fitness in patients with obesity. |
-
-
- Original Article
- Pulmonology
- Nonlinear association between neutrophil-to-lymphocyte ratio and asthma in children and adolescents in the United States: a cross-sectional study
(30 times)
-
Chuhan Cheng, Liyan Zhang
-
Clin Exp Pediatr. 2025;68(7):489-496. Published online March 11, 2025
-
|
Question: Is there a nonlinear relationship between neutrophil-to-lymphocyte ratio (NLR) and asthma in children and adolescents?
Finding: NLR showed a nonlinear association with asthma, with an NLR threshold of 2.23 identifying individuals at higher risk.
Meaning: An NLR<2.23 may serve as a potential biomarker for asthma risk assessment and management in pediatric populations, thereby offering a simple tool for the early identification of at-risk individuals. |
-
-
- General Pediatrics
- Trends and determinants in breastfeeding among Korean infants (2007–2021): a nationwide study using the National Health Screening Program for Infants and Children
(30 times)
-
Minwoong Kang, Eui Kyung Choi, Jeung Min Lee, Hye-Jung Shin, Woo Ryoung Lee, Son Moon Shin; Korean Society of Breastfeeding Medicine
-
Clin Exp Pediatr. 2025;68(10):772-780. Published online July 4, 2025
-
|
Question: What are the recent trends and determinants of breastfeeding in South Korea?
Finding: Breastfeeding rates in South Korea declined significantly from 2007 to 2021, with lower rates observed in preterm, low-birthweight, and multiple-birth infants as well as rural or lower-income households.
Meaning: Targeted interventions, including prenatal education, postnatal support, and community-based programs, are required to address disparities and improve breastfeeding rates. |
-
-
- Endocrinology
- Long-term epidemiological insights into rickets: a nationwide population-based retrospective study
(30 times)
-
Chun-Hao Chu, Ying-Chuan Chen, Pei-Yao Liu, Chun-Chieh Hu, Yu-Lung Lin, Feng-Chih Kuo, Chieh-Hua Lu, Tzu-Ju Hsu, Yu-Tung Hung, Fuu-Jen Tsai, Chien-Ming Lin
-
Clin Exp Pediatr. 2025;68(11):879-891. Published online August 20, 2025
-
|
Question: What are the nationwide trends and mortality risk factors of nutritional versus hereditary rickets among children in Asia?
Finding: In 2012–2018, the incidence of rickets steadily increased, whereas mortality rates declined. Mortality is associated with a low household income, anemia, chronic kidney disease, secondary hyperparathyroidism, and a prolonged hospital stay.
Meaning: Early diagnosis and targeted interventions addressing social and medical vulnerabilities are critical to reducing ricket-related mortality. |
-
-
- Review Article
- Other
- Virtual reality for managing pain and fear and anxiety during pediatric needle procedures: an umbrella review
(30 times)
-
Thomas Saliba, Guillaume Fahrni
-
Clin Exp Pediatr. 2026;69(8):609-621. Published online July 14, 2026
-
|
Meta-analyses suggest that virtual reality (VR) reduces self-reported pain, fear, and anxiety in children during needle procedures but has high heterogeneity, high overlap between primary studies, and low methodological quality, leading to a "very weak" GRADE (Grading of Recommendations Assessment, Development and Evaluation) classification. Clinicians should view VR as a promising additional distraction tool; however, VR cannot yet replace current analgesic and anxiolytic strategies. Future research should focus on age-stratified analyses, measurement tool standardization, and modern VR technology |
-
-
- Original Article
- Other
- Comparing ethyl chloride and 10% lignocaine spray for pediatric intravenous cannulation pain relief
(30 times)
-
Susmitha Vellanki, Malavika Kulkarni, H.D. Arun Kumar, Deepali Shetty, Nikhil Karthik B, Mathew Tom
-
Clin Exp Pediatr. 2026;69(1):65-72. Published online November 21, 2025
-
|
Background: Intravenous cannulation (IVC) is a routine yet distressing procedure in pediatric patients, often provoking significant anxiety and procedural pain. Although eutectic mixtures such as eutectic mixture of local anesthetic cream are widely used, their delayed onset limits their applicability in time-sensitive settings. Ethyl chloride vapocoolant spray and 10% lignocaine spray have been proposed as rapid-onset alternatives, yet direct comparative... |
-
-
- Neurology
- Instability of revised Korean Developmental Screening Test classification in first year of life
(29 times)
-
Ji Eun Jeong, You Min Kim, Na Won Lee, Gyeong Nam Kim, Jisuk Bae, Jin Kyung Kim
-
Clin Exp Pediatr. 2025;68(1):97-103. Published online November 11, 2024
-
|
Question: How stable are the revised Korean Developmental Screening Test score classifications in early infancy?
Finding: A significant number of infants improved into the peer and high-level group (≥-1 standard deviations), especially in the gross motor area.
Meaning: The early detection of developmental delay requires a comprehensive medical history, physical and neurological examinations, and repeated developmental screenings. |
-
-
- Editorial
- Neurology
- Tocilizumab as a key therapeutic option in high-risk pediatric acute necrotizing encephalopathy
(29 times)
-
Jon Soo Kim
-
Clin Exp Pediatr. 2026;69(2):114-116. Published online January 26, 2026
-
|
· Acute necrotizing encephalopathy (ANE) is a severe, infection- triggered encephalitis driven primarily by cytokine- mediated immune dysregulation rather than direct viral cytotoxicity.
· Tocilizumab, through targeted inhibition of interleukin-6 signaling, is an important therapeutic option for ANE that may improve survival and neurological outcomes of high-risk pediatric patients. |
-
-
- Original Article
- Neonatology (Perinatology)
- Efficacy and safety of home-based fiberoptic blanket versus hospital-based light-emitting diode phototherapy for neonatal jaundice: a retrospective cohort study from Thailand
(29 times)
-
Chayatat Ruangkit, Thanyathorn Thaninjeerawat, Saitarn Klaidangklum, Saowalak Prasopa, Pongsakorn Atiksawedparit, Sasivimon Soonsawad
-
Clin Exp Pediatr. 2026;69(8):655-664. Published online July 1, 2026
-
|
Question: Is a home-based fiberoptic phototherapy blanket as effective and safe as hospital-based overhead light-emitting diode phototherapy for the treatment of neonatal jaundice?
Finding: Home phototherapy (HPT) resulted in a slower bilirubin reduction rate than inpatient phototherapy (IPT); however, both modalities achieved the therapeutic targets without phototherapy-related complications.
Meaning: With careful patient selection, structured monitoring, and reliable follow-up, HPT is a safe and feasible alternative to IPT for neonatal jaundice. |
-
-
- Nutrition
- Energy drink consumption among Korean adolescents: prevalence and associated factors
(28 times)
-
Jee-Seon Shim, Jeong Mi Lee
-
Clin Exp Pediatr. 2024;67(10):531-539. Published online September 24, 2024
-
|
Question: How prevalent is energy drink consumption among Korean adolescents and what are the associated factors?
Findings: The prevalence of energy drink consumption among Korean adolescents increased from 3.2% in 2014 to 12.2% in 2019. Energy drink consumption varies according to sociode-mographic and individual factors.
Meaning: Policies and educational strategies are needed to reduce energy drink consumption in adolescents. |
-
-
