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Articles in E-pub version are posted online ahead of regular printed publication.

Editorial
Impact of coronavirus disease 2019 on children’s health
Joon Won Kang
· Coronavirus disease 2019 (COVID-19) has had an enormous impact on mental health and other aspects of children’s health.
· The prevalence of anxiety, depression, and posttraumatic stress disorder in children and adolescents have increased in the COVID-19 era.
· Cooperation among parents, guardians, academic societies, and the government is needed to maintain the mental health of children and adolescents.
DOI: https://doi.org/10.3345/cep.2022.00682    [Epub ahead of print]
Editorial
Hypertension in adulthood is programmed during the perinatal period
Min Hyun Cho
∙ Intrauterine growth restriction (IUGR) and preterm birth can be significant risk factors for the development of adult hypertension.
∙ Several perinatal factors of hypertension are related to IUGR, including renal, vascular, and rapid catch-up growth.
DOI: https://doi.org/10.3345/cep.2022.00829    [Epub ahead of print]
Original Article
Mediation effect of cord blood cortisol levels between maternal prepregnancy body mass index and birth weight: a hospital-based cross-sectional study
Nisanth Selvam, Jayashree K, Prasanna Mithra
Question: What is the association between cord blood cortisol and maternal weight, birth weight, and cord blood lipid profile?
Finding: Cord blood cortisol levels did not influence the relationship between maternal weight changes or birth weight. Maternal weight changes, birth weight, and cortisol levels altered the cord blood lipid profile.
Meaning: Our findings may aid United Nations Sustainable Development Goal 3 (Good Health and Well-Being) achievement by 2030.
DOI: https://doi.org/10.3345/cep.2022.00122    [Epub ahead of print]
Editorial
Three-dimensional printing technolgy in orthopedic oncology
Yongsung Kim
Orthopedic oncology is one of the most active fields in applying 3-dimensional printing technology from preoperative planning to intraoperative procedures such as accurate resection of tumors and reconstruction of huge bone defects.
DOI: https://doi.org/10.3345/cep.2022.00080    [Epub ahead of print]
Review Article
Rotavirus infection-associated central nervous system complications: clinicoradiological features and potential mechanisms
Kyung Yeon Lee
∙ Rotavirus infection-associated central nervous system (CNS) complications are fairly common in children.
∙ Common clinicoradiological features include benign convulsions with mild gastroenteritis, acute encephalopathies/encephalitis, cerebellitis, and neonatal rotavirus-associated leukoencephalopathy.
∙ Possible mechanisms for CNS complications include direct viral invasion into the brain via several potential routes such as the blood-brain barrier and vagus nerve, and entry of various brain-damaging mediators and activated immune cells into the brain.
DOI: https://doi.org/10.3345/cep.2021.01333    [Epub ahead of print]
Update on benign convulsions with mild gastroenteritis
Yeong Seok Lee, Ga Hee Lee, Young Se Kwon
∙ The main pathogen for benign convulsions with mild gastroenteritis (CwG) was previously rotavirus; however, cases associated with norovirus are increasing.
∙ CwG is characterized by clustered generalized seizures. Electroencephalography and magnetic resonance imaging show transiently abnormal findings in the acute phase that eventually normalize with progression. Its prognosis is good, and long-term treatment is unnecessary.
∙ There are many reports on the pathophysiological mechanism of CwG, which remains unclear.
DOI: https://doi.org/10.3345/cep.2021.00997    [Epub ahead of print]
Application of 3-dimensional printing implants for bone tumors
Jong Woong Park, Hyun Guy Kang
∙ The application of 3-dimensional (3D) printing in orthopedic oncology is summarized into bone and tumor modeling, patient-specific instruments (PSIs), custom-made implants, and tissue engineering.
∙ The 3D-printed customized implant is the most central application, while modeling and PSI often play adjunct roles.
∙ Short-term surgical outcomes of custom-made 3D-printed implants are promising.
DOI: https://doi.org/10.3345/cep.2021.01326    [Epub ahead of print]
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