Clinical and Experimental Pediatrics

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Articles in E-pub version are posted online ahead of regular printed publication.

Original Article

Treatment targeting pediatric inflammatory bowel disease-associated anemia: experience from a single tertiary center

Ana S.C. Fernandes, Sara Azevedo, Ana Rita Martins, Ana Isabel Lopes

Question: Does treating iron deficiency (ID) using intravenous iron in pediatric inflammatory bowel disease (IBD) feature long-term safety and efficacy?
Finding: Intravenous iron supplementation was safe and effective. However, the ID recurrence rate was higher than expected.
Meaning: Proactive screening and treatment of ID in pediatric IBD are essential. The Ganzoni formula likely underestimates the iron requirements of pediatric patients. Prospective trials are needed to optimize iron treatment dosing.

DOI: https://doi.org/10.3345/cep.2025.00640 [Epub ahead of print]

Role of neutrophil elastase in predicting infection among children with chemotherapy-induced febrile neutropenia

Mahmoud A. El-Hawy, Doaa M. Elian, Mai El-Sayad Abd El-Hamid, Esraa T. Allam, Mariam S. Kandeel, Asmaa A. Mahmoud

Background: Infection is a significant cause of death following chemotherapy-induced febrile neutropenia (FN). Neutropenia and compromised neutrophil function are the primary reasons for the decreased defense against infections.
Purpose: This study aimed to evaluate the significance of neutrophil elastase (NE) in predicting the outcomes of childhood hematological malignancies with FN. Methods: The study included 64 patients with FN and 64 healthy children...

DOI: https://doi.org/10.3345/cep.2025.00318 [Epub ahead of print]

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Treatment targeting pediatric inflammatory bowel disease-associated anemia: experience from a single tertiary center

Role of neutrophil elastase in predicting infection among children with chemotherapy-induced febrile neutropenia

Artificial Intelligence in Pediatric Healthcare: current applications, potentials and implementation considerations

Effect of postoperative enteral protein supplementation on nitrogen balance in critically ill children

Adenosine deaminase and interleukin-1 receptor antagonist genetic polymorphisms among obese children with versus without metabolic dysfunction–associated fatty liver disease

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Clinical and Experimental Pediatrics is an open access journal. All articles are distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/)