Most cited
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most cited
Most-cited articles are from the articles published during the last two years (2024 ~ ).
- Original Article
- Neonatology (Perinatology)
- Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis
-
Asha P. Shetty, Kurvatteppa Halemani, Alwin Issac, Latha Thimmappa, Sanjay Dhiraaj, Radha K, Prabhaker Mishra, Vijai Datta Upadhyaya
-
Clin Exp Pediatr. 2024;67(2):104-115. Published online November 14, 2023
-
|
Question: What emotions do parents experience when their newborns are admitted to the neonatal intensive care unit (NICU)?
Finding: Mothers experienced more anxiety (51%), depression (31%), and stress (41%) symptoms than fathers (26%, 12%, and 22%, respectively).
Meaning: Parents often experience anxiety, stress, and depression following NICU admission. Healthcare workers are responsible for providing regular parental counseling. |
-
-
- Review Article
- Other
- Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies
-
Rogers Wainkwa Chia, Ntegang Venant Atem, Jin-Yong Lee, Jihye Cha
-
Clin Exp Pediatr. 2025;68(1):1-15. Published online November 6, 2024
-
|
· Milk and formula are common sources of microplastic in infants.
· Water and air are the most common sources of microplastic pollution from infancy to adolescence.
· Microplastic use by children of all ages can cause cell damage and affect their health.
· Microplastics present in children can be quantified using a stereomicroscope and characterized using micro- Fourier transform infrared spectroscopy. |
-
-
- Infection
- Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment
-
Ki Wook Yun
-
Clin Exp Pediatr. 2024;67(2):80-89. Published online June 14, 2023
-
|
· Most commonly confirmed causes of community-acquired pneumonia (CAP) in children are Mycoplasma pneumoniae (8%–40%) and respiratory syncytial virus (15%–20%).
· Pyogenic bacteria, most commonly Streptococcus pneumoniae (40%–50%) and Streptococcus pyogenes (10%–25%), are detected in 2%–5% of children hospitalized with CAP.
· CAP should be diagnosed conservatively according to clinical and radiological criteria.
· The etiology should be identified via appropriate test result interpretation. |
-
-
- Genetics and Metabolism
- Development of orphan drugs for rare diseases
-
Han-Wook Yoo
-
Clin Exp Pediatr. 2024;67(7):315-327. Published online June 28, 2023
-
|
· Orphan disease is a rare disease, primarily affecting newborn and children. Vast majority of orphan diseases has genetic background.
· Orphan disease is individually rare. But as a whole, it is not rare, becoming a great socioeconomic burden.
· The diagnosis of rare genetic disease has been problematic, but recent progress of genome analysis technologies makes it faster and more precise.
· There are many unmet needs as to the curative treatment. However, the number of treatable rare diseases is growingly increasing owing to the development of biotechnology.
· Most orphan drugs are extremely expensive because of numer ous hurdles during the process of drug development as well as small number of patients. |
-
-
- General Pediatrics
- Metabolic complications of obesity in children and adolescents
-
Hyunjin Park, Jung Eun Choi, Seunghee Jun, Hyelim Lee, Hae Soon Kim, Hye Ah Lee, Hyesook Park
-
Clin Exp Pediatr. 2024;67(7):347-355. Published online November 16, 2023
-
|
· Pediatric obesity increases the risk of metabolic complications (insulin resistance, dyslipidemia, nonalcoholic fatty liver disease) and long-term cardiovascular diseases.
· A new obesity definition and various indicators (continuous metabolic syndrome score, pediatric simple metabolic syndrome score, fatty liver index) have been proposed to evaluate children’s susceptibility to metabolic disorders.
· Laboratory and body composition tests in pediatric screenings can identify groups at high risk of metabolic complications of obesity. |
-
-
- Neonatology (Perinatology)
- Neonatal family-centered care: evidence and practice models
-
Juyoung Lee
-
Clin Exp Pediatr. 2024;67(4):171-177. Published online June 14, 2023
-
|
· Concrete evidence exists of early parent-infant attachment supported by family-centered care (FCC) in the neonatal intensive care unit.
· FCC involves the parents’ presence and participation in the infant’s care and decision-making.
· A private and comfortable space should be provided. A single-family room is ideal; however, a quiet space with a recliner can be a good alternative.
· Care culture changes and staff training are required. |
-
-
- Developmental and Behavioral Medicine
- Clinical practice guidelines for attention-deficit/hyperactivity disorder: recent updates
-
Tae Hoon Eom, Young-Hoon Kim
-
Clin Exp Pediatr. 2024;67(1):26-34. Published online June 14, 2023
-
|
· Primary pediatricians should play a key role in the diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD).
· The Diagnostic and Statistical Manual of Mental Disorders, fifth edition, has lowered the diagnostic threshold for older teens and adults and a comorbid diagnosis with autism is now allowed.
· The American Academy of Pediatrics had added recommendation-related comorbid conditions in its guideline and the Society of Developmental and Behavioral Pediatrics recently developed a complex ADHD guideline.
· The European ADHD Guideline Group recently developed a guideline for managing ADHD during the coronavirus disease 2019 pandemic. |
-
-
- Allergy
- Global burden of asthma among children and adolescents with projections to 2050: a comprehensive review and forecasted modeling study
-
Tae Hyeon Kim, Hyunjee Kim, Jiyeon Oh, Soeun Kim, Michael Miligkos, Dong Keon Yon, Nikolaos G Papadopoulos
-
Clin Exp Pediatr. 2025;68(5):329-343. Published online April 22, 2025
-
|
Pediatric asthma can persist to adulthood and must be effectively managed. This review examined the prevalence of asthma among individuals younger than 20 years and revealed a decline from 1990 to 2021, higher rates in males, and a peak in children aged 5–9 years. Despite a projected continued decrease in prevalence by 2050, asthma will remain a significant health concern for children and adolescents. |
-
-
- Endocrinology
- Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and
neurodevelopmental outcomes: an extensive review
-
Ozge Yesildemir, Mensure Nur Celik
-
Clin Exp Pediatr. 2024;67(7):328-346. Published online November 16, 2023
-
|
· Sensitivity to endocrine-disrupting chemical (EDC) exposure increases during critical developmental periods (in embryos, fetuses, and neonates).
· Pre- and postnatal exposure to EDCs is associated with fetal growth restriction, preterm birth, and low birth weight.
· Exposure to EDCs during fetal and early postnatal life can have lasting and lifelong neurodevelopmental outcomes, including autism spectrum, attention deficit hyperactivity, and other cognitive and behavioral disorders. |
-
-
- Other
- Use of virtual reality in children in a broad range of medical settings: a systematic narrative review of recent meta-analyses
-
Emily Antonovics, Grammatina Boitsios, Thomas Saliba
-
Clin Exp Pediatr. 2024;67(6):274-282. Published online May 21, 2024
-
|
· Virtual reality (VR) is becoming increasingly common for entertainment and in medical settings.
· VR is useful for treating children with cerebral palsy.
· VR can help with attention deficit/hyperactivity disorder symptoms.
· VR can decrease pain perception in children undergoing burn wound care.
· VR can reduce preoperative anxiety.
· VR can reduce fear and pain during needle-involving procedures. |
-
-
- Allergy
- Skin and oral intervention for food allergy prevention based on dual allergen exposure hypothesis
-
Kiwako Yamamoto-Hanada, Yukihiro Ohya
-
Clin Exp Pediatr. 2024;67(10):477-485. Published online June 14, 2023
-
|
To prevent food allergy in infants, based on the dual allergen exposure hypothesis, we recommend a personalized approach consisting of both skin intervention (eczema treatment to achieve early remission and well-controlled skin without eczema to prevent percutaneous immunoglobulin E sensitization) and oral intervention (early allergenic food introduction). |
-
-
- Original Article
- Neurology
- Effectiveness of Helmet therapy for infants with moderate to severe positional plagiocephaly
-
Jeongho Kim, Jina Kim, Kyu Young Chae
-
Clin Exp Pediatr. 2024;67(1):46-53. Published online December 5, 2023
-
|
Question: Is helmet therapy effective for positional plagiocephaly? What factors influence helmet therapy efficacy for positional plagiocephaly?
Finding: Helmet therapy is effective for infants with moderate to severe positional plagiocephaly, and its effectiveness is influenced by age at treatment initiation, severity of head asymmetry, and daily duration of helmet wear.
Meaning: Pediatricians should initiate helmet therapy for positional plagiocephaly sooner, ideally before 9 months of age, to maximize treatment efficacy. |
-
-
- Review Article
- Other
- MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases
-
Hwal Rim Jeong, Il Tae Hwang
-
Clin Exp Pediatr. 2024;67(3):119-125. Published online May 24, 2023
-
|
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post transcriptionally, and MiRNA expression levels vary with developmental stages. MiRNAs play an important role in several biological processes in children, including growth, neuro-development, inflammation, and tumor formation. Research on miRNAs may uncover the molecular mechanisms underlying various pediatric diseases, leading to the development of novel biomarkers that aid in the diagnosis, treatment, and prognosis of these diseases. |
-
-
- Neonatology (Perinatology)
- Demographic transition in South Korea: implications of falling birth rates
-
Chae Young Kim, Sung-Hoon Chung
-
Clin Exp Pediatr. 2024;67(10):498-509. Published online June 27, 2024
-
|
· Since 1960, South Korea's TFR decreased from 6.33 to 0.78 in 2022, below the 2.1 replacement level since 1983, with women's average age at first marriage rising to 31.3 in 2022.
· Policies needed: financial incentives, longer parental leave, better childcare.
· The U.S. (15.3% immigrants) and Germany (18.8%) use immigration to maintain demographic stability, a strategy South Korea is considering. |
-
-
- Cardiology
- Heart failure in children and adolescents: an update on diagnostic approaches and management
-
Amit Agrawal, Dalwinder Janjua, Abdulrahman Ahmed Alsayed Ali Zeyada, Ahmed Taher Elsheikh
-
Clin Exp Pediatr. 2024;67(4):178-190. Published online June 19, 2023
-
|
· Pediatric heart failure (PHF) is a clinical syndrome featuring various symptoms (shortness of breath, ankle swelling, fatigue) and signs (pulmonary crackles, peripheral edema).
· Congenital heart diseases are the most common underlying etiology of PHF, whereas myocarditis and primary cardio-myopathies are common in children without structural ab-normalities.
· PHF pathophysiology is complex and multifactorial and varies by etiology and age.
· PHF management includes decongestive therapy, treatment of underlying causes, preventing progression, and managing pulmonary or systemic obstructions.
· Drugs should be chosen based on pharmacodynamics, clinical manifestations, hemodynamic state, and renal function. |
-
-
- Review Article
- Developmental and Behavioral Medicine
- Screen time among preschoolers: exploring individual, familial, and environmental factors
-
Sangha Lee, Donghee Kim, Yunmi Shin
-
Clin Exp Pediatr. 2024;67(12):641-650. Published online September 12, 2024
-
|
|
This systematic review examined the correlation between screen time and various factors in preschoolers. Findings suggest that media parenting, including setting appropriate media limits, is crucial in protecting against excessive screen exposure. However, limited research has been done on the impact of family and personal factors, particularly with the increasing use of portable devices among young children. |
-
-
- Comprehensive evaluation of the child with global developmental delays or intellectual disability
-
Abdullah Nasser Aldosari, T. Saeed Aldosari
-
Clin Exp Pediatr. 2024;67(9):435-446. Published online May 29, 2024
-
|
· A detailed history and comprehensive physical examination remain the cornerstones for establishing a diagnosis of global developmental delay/intellectual disability (GDD/ID).
· Comprehensive surveillance and screening programs play a significant role in the early detection of GDD.
· Whole-exome sequencing is highly recommended as first- or second-line testing for individuals with idiopathic GDD/ID.
· Early intervention by a well-versed multidisciplinary team can significantly improve the outcomes and prognosis of GDD/ID. |
-
-
- Hematology
- Iron deficiency in children with a focus on inflammatory conditions
-
Na Hee Lee
-
Clin Exp Pediatr. 2024;67(6):283-293. Published online May 21, 2024
-
|
· Iron deficiency has important effects on neurodevelopment and the immune system in children.
· Hepcidine plays an important role in iron homeostasis.
· Diagnosis and treatment of iron deficiency in chronic inflammatory disease are important for patients' quality of life and disease course. |
-
-
- Neonatology (Perinatology)
- Updates in neonatal resuscitation: routine use of laryngeal masks as an alternative to face masks
-
Eun Song Song, Ga Won Jeon
-
Clin Exp Pediatr. 2024;67(5):240-246. Published online July 11, 2023
-
|
In neonatal resuscitation:
· Laryngeal masks are recommended when endotracheal intubation or positive-pressure ventilation fails.
· Laryngeal masks are useful even during chest compressions.
· Laryngeal masks aid neonates >34 weeks’ gestation and/or with a birth weight >2 kg.
· Main usage barriers include limited experience (81%), preference for endotracheal tubes (57%), and lack of awareness (56%).
· Second-generation laryngeal masks have a built-in esophageal drainage tube that prevents regurgitation into the glottis, and an orogastric tube can be inserted within the esophageal drainage tube to protect against gastric inflation. |
-
-
- Original Article
- Pulmonology
- Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia
-
Jeong Eun Shin, Soon Min Lee, Mi-Jung Lee, Jungho Han, Joohee Lim, Haerin Jang, Ho Seon Eun, Min Soo Park, Soo Yeon Kim, Myung Hyun Sohn, Ji Ye Jung, Kyung Won Kim
-
Clin Exp Pediatr. 2024;67(5):257-266. Published online April 16, 2024
-
|
Question: Is bronchopulmonary dysplasia (BPD) associated with functional/structural abnormalities later in life?
Finding: School-aged children with severe BPD had abnormalities on pulmonary function tests and lung computed tomography despite no subjective respiratory symptoms; however, only prenatal oligohydramnios and prolonged ventilator use were associated with abnormal lung function.
Meaning: Long-term monitoring of preterm infants’ lung health is essential, especially for those with prenatal oligohydramnios or prolonged ventilator use. |
-
-
- Neonatology (Perinatology)
- Oral administration of bone marrow-derived mesenchymal stem cells attenuates intestinal injury in necrotizing enterocolitis
-
Yeong Seok Lee, Yong Hoon Jun, Juyoung Lee
-
Clin Exp Pediatr. 2024;67(3):152-160. Published online February 19, 2024
-
|
Question: What is the optimal dose of bone marrow-derived mesenchymal stem cells (BM-MSCs) for treating necrotizing enterocolitis (NEC), and is orally administered BM-MSC effective?
Findings: High (1×106 cells) or multiple BM-MSC doses showed similar effects as low (1×105 cells) doses of intraperitoneally administered BM-MSCs. Furthermore, orally administered BM-MSCs were as effective as intraperitoneally administered BM-MSCs.
Meaning: Orally administered low-dose BM-MSCs are a potential treatment for NEC. |
-
-
- Other
- Virtual, augmented, and mixed reality: potential clinical and training applications in pediatrics
-
Suyoung Yoo, Meong Hi Son
-
Clin Exp Pediatr. 2024;67(2):92-103. Published online May 24, 2023
-
|
· Review of articles that investigated the applications of virtual, augmented, or mixed reality in pediatric clinical settings and in the training of pediatric medical professionals was conducted.
· A total of 89 studies were retrieved, with 36 randomized controlled trials.
· In most studies, intervention using the novel technology was at least as effective or more effective than the traditional method.
· Use of virtual, augmented, and mixed reality has potential in pediatrics. |
-
-
- Review Article
- Infection
- COVID-19 among infants: key clinical features and remaining controversies
-
Nevio Cimolai
-
Clin Exp Pediatr. 2024;67(1):1-16. Published online November 27, 2023
-
|
· Clinical studies of coronavirus disease 2019 (COVID-19) in infants should be supported by rigorous laboratory diagnostic criteria.
· Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads to infants similarly to other viral respiratory infections.
· Among infants ≤1 year of age beyond the immediate postpartum period, COVID-19 is relatively mild, but even the low risk of severe disease requires prevention.
· Comorbidities increase infection vulnerability and complications in infants.
· Clinical and laboratory data do not sufficiently distinguish COVID-19 from other respiratory viral infections.
· Coinfection with SARS-CoV-2 is uncommon among infants.
· Unique infection sequelae, including multi-inflammatory syndrome in children and neonates and long COVID require further study and refinement of diagnostic criteria.
· Infection control standards applied to mother-infant dyads should be tempered by standard preventive strategies, maternal input, accommodation potential, and overall safety.
· Maternal vaccination prevents disease in early infancy. |
-
-
- Gastroenterology
- Anxiety disorders presenting as gastrointestinal symptoms in children – a scoping review
-
Anjali Kumar, Pramodh Vallabhaneni
-
Clin Exp Pediatr. 2025;68(5):344-351. Published online January 13, 2025
-
|
A positive bidirectional relationship between gastrointestinal disorders and anxiety, but with no clear aetiology, was identified. Factors such as somatisation and pain catastrophising resulted in poorer pain-related outcomes in children. Further studies are required to understand this relationship in order to have targeted treatments and ensure better long term outcomes. |
-
-
- Other
- Global trends in importance of 24-hour movement behaviors to pediatric health: implications for South Korea
-
Eun-Young Lee, Reyana Jayawardena, Seiyeong Park, Justin Y Jeon, Yeon-Soo Kim, Mark S. Tremblay
-
Clin Exp Pediatr. 2025;68(1):16-29. Published online November 11, 2024
-
|
· The 24-hour movement behavior paradigm provides an important framework for future pediatric health promotion efforts.
· Policy priorities should include advancing surveillance and monitoring assessments related to 24-hour movement behaviors, evaluating their implementation in school and government policies, and building preparedness for future pandemics and natural disasters, including climate change, by promoting healthy 24-hour movement behaviors.
· Future research should advocate for the promotion of 24- hour movement behaviors. |
-
-
- Allergy
- Comparison and review of international guidelines for treating asthma in children
-
Eui Jeong Roh
-
Clin Exp Pediatr. 2024;67(9):447-455. Published online August 20, 2024
-
|
Asthma is the most common chronic disease among children. Although asthma in children may spontaneously improve, it continues into adulthood in many cases. Therefore, appropriate disease management and medication are essential. Consistent and objective guidelines are needed to manage pediatric asthma and related adverse reactions. |
-
-
- Original Article
- Endocrinology
- Kisspeptin and DLK1 levels for monitoring treatment of girls with central precocious puberty
-
Witchuwan Onsoi, Nattakarn Numsriskulrat, Suphab Aroonparkmongkol, Vichit Supornsilchai, Khomsak Srilanchakon
-
Clin Exp Pediatr. 2024;67(6):296-302. Published online May 21, 2024
-
|
Questions: Can the serum levels of kisspeptin and DLK1 be potential biomarkers for monitoring the treatments for central precocious puberty (CPP)?
Findings: There were no significant differences in the baseline serum kisspeptin and DLK1 levels in CPP girls compared to girls with premature thelarche (PT). After 6 months of GnRH analogue treatment in CPP girls, median serum kisspeptin levels decreased, while median serum DLK1 levels increased compared to baseline.
Meanings: Serum levels of kisspeptin and DLK1 may serve as novel biomarkers for monitoring the efficacy of treatments for CPP. |
-
-
- Review Article
- Neonatology (Perinatology)
- Influence of infant microbiome on health and development
-
Noelle Younge
-
Clin Exp Pediatr. 2024;67(5):224-231. Published online August 21, 2023
-
|
· The infant gut microbiome is highly dynamic and individualized.
· Microbes are vertically transmitted from mother to infant during delivery and throughout infancy.
· Delivery mode, gestational age, diet, and antibiotic use influence infant microbiome composition and function.
· In animal studies, the microbiome played critical roles in the structural and functional development of the infant gastrointestinal and immune systems.
· Microbiome-targeted therapies have great potential to reduce infant morbidity and mortality. |
-
-
- Gastroenterology
- High-resolution anorectal manometry in children
-
Yogesh Waikar
-
Clin Exp Pediatr. 2024;67(2):57-63. Published online June 14, 2023
-
|
· Anorectal manometry is safe in children.
· Defecation Dyssynergia is one of the commonest cause of chronic constipation.
· Positive Rectoanal inhibiory reflex rules out Hirschsprung's Disease |
-
-
