Clinical and Experimental Pediatrics

Original Article

Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia

Yu-Chun Cheng, Yun-Ju Lai, Wei-Shiung Lian, Ching-Chang Tsai, Hsin-Hsin Cheng, Hong-Ren Yu, Mao-Meng Tiao, Jiunn-Ming Sheen, Ying-Lun Hsu, Feng-Sheng Wang, I-Chun Lin

Background: Preeclampsia (PE) is a serious complication of pregnancy that affects the offspring and mothers. Those with a history of PE are at higher risk of future cardiometabolic diseases, the etiology of which remains uncertain.
Purpose: To investigate the transcriptomic profiles of mothers and neonates to determine whether certain genes are commonly affected after shared exposure to PE. Methods: In this observational...

DOI: https://doi.org/10.3345/cep.2025.02565 [Accepted]

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Long-term outcome in children with infantile epileptic spasms syndrome: a multicenter retrospective study in Korea

Sun Ah Choi, Minhye Kim, Hye Jin Kim, Woo Joong Kim, Byung Chan Lim, Ji Yeon Han, Hunmin Kim, Min-Jee Kim, Mi-Sun Yum, Jiwon Lee, Jeehun Lee, Hyewon Woo, Jon Soo Kim

Background: Infantile epileptic spasms syndrome (IESS) is a severe form of infantile epilepsy with a high lifetime morbidity burden.
Purpose: We aimed to assess the long-term epilepsy and neurodevelopmental outcomes based on how children with IESS have been managed over the past few decades. Methods: This retrospective multicenter study included children diagnosed with IESS between 1994 and 2021 with a minimum follow-up...

DOI: https://doi.org/10.3345/cep.2025.02089 [Accepted]

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Validation of a new Japanese classification for predicting severe bronchopulmonary dysplasia in preterm infants

Masato Ito, Shinya Hirano, Fumihiko Namba

Background: Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in very preterm infants; however, conventional classifications have limited ability to predict severity before 36 weeks' postmenstrual age (PMA). A new Japanese classification, based on small for gestational age (SGA), bubbly/cystic chest radiographic findings, and chorioamnionitis (CAM), was proposed to enable earlier risk stratification. However, its validation in homogeneous cohorts is warranted.
Purpose: This study aimed to examine...

DOI: https://doi.org/10.3345/cep.2025.02642 [Accepted]

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Hemodynamics and cerebral oxygenation in the neonatal transition: a prospective pilot study

Daniel Pfurtscheller, Christoph Schlatzer, Nina Höller, Bernhard Schwaberger, Lukas Mileder, Nariae Baik-Schneditz, Magdalena Holter, Gerhard Pichler

Background: The impact of arterial blood pressure on cerebral oxygenation during immediate postnatal transition is poorly understood.
Purpose: Here we investigated the association between arterial blood pressure (BP), cerebral tissue oxygenation index (cTOI), and cerebral fractional tissue oxygen extraction (cFTOE) during the immediate postnatal transition in preterm and full-term neonates. Methods: This prospective observational study included preterm and term neonates who did...

DOI: https://doi.org/10.3345/cep.2025.02572 [Accepted]

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Influence of atrial septal defect on mitral valve growth after repair of coarctation of the aorta or an interrupted aortic arch in infants

Yi-Chia Wang, Hen-Wen Chou, Chi-Hsiang Huang, Hsing-Hao Huang, Yih-Sharng Chen, En-Ting Wu, Shyh-Jye Chen, Ming-Tai Lin, Shuenn-Nan Chiu, Shu-Chien Huang

Background: Patients with coarctation of the aorta (CoA) and an interrupted aortic arch (IAA) may present with small mitral valves (MVs) and a reduced left ventricular (LV) volume. Biventricular repair (BVR) in these patients is dependent on adequate size of the left cardiac structures.
Purpose: This study evaluated the impact of the hemodynamic characteristics of atrial septal defects (ASDs) on MV...

DOI: https://doi.org/10.3345/cep.2025.02110 [Accepted]

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Prolonged cerebral oxygenation surveillance with algorithm-based management: a neurocritical care bundle for extremely preterm infants

Kai-Hsiang Hsu, Wei-Hung Wu, Shu-Yu Lin, Chih-Chen Chang, Mei-Yin Lai, I-Hsyuan Wu, Shih-Ming Chu, Ming-Chou Chiang, Reyin Lien

Background: Cerebral hypoxia-ischemia impairs brain development in extremely preterm infants and is associated with poor neurological outcomes. Near-infrared spectroscopy (NIRS) is a noninvasive continuous monitoring method for regional cerebral oxygen saturation (rcSO2).
Purpose: This study evaluated the clinical feasibility and neurological impact of a neurocritical care bundle that incorporates prolonged multidisciplinary hemodynamic monitoring and a stepwise management algorithm. Methods: Preterm infants with...

DOI: https://doi.org/10.3345/cep.2025.02117 [Accepted]

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Perinatal risk factors for hemodynamically significant patent ductus arteriosus in very low birth weight infants

Jie Hee Jue, So Young Shin, Jae Hyun Park, Chun Soo Kim, Hee Joung Choi

Background: Multiple perinatal factors influence hemodynamically significant patent ductus arteriosus (HS PDA) in preterm infants.
Purpose: This study aimed to identify the risk factors associated with HS PDA in very low birth weight infants (VLBWIs) and determine the predictors of surgical ligation. Methods: This retrospective study included VLBWIs born at 23–32 weeks’ gestation whose HS PDA properties could be identified using...

DOI: https://doi.org/10.3345/cep.2025.01893 [Accepted]

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Cited By 37	Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis
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Accepted articles