| Effect of postoperative enteral protein supplementation on nitrogen balance in critically ill children |
Irene Yuniar 
, Kadek Apik Lestari
, Antonius Hocky Pudjiadi
, Fatima Safira Alatas
, Yoga Devaera
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Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Correspondence:
Kadek Apik Lestari, Email: kadekapiklestari@gmail.com
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Received: 26 January 2025 • Revised: 20 April 2025 • Accepted: 8 May 2025 |
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| Abstract |
Background
Critically ill children are at risk of postoperative malnutrition. Thus, optimal nutritional therapy is essential for preventing morbidity development and reducing mortality rates among this population. An adequate protein intake increases anabolism. However, data on the effect of enteral protein supplementation on nitrogen balance and intestinal fatty acid–binding protein (I-FABP) levels in postoperative critically ill children remain limited.
Purpose
This study aimed to analyze whether an increased protein intake via enteral nutrition improves nitrogen balance and reduces serum I-FABP levels among postoperative critically ill children.
Methods
This double-blind randomized controlled trial examined critically ill children aged 1–5 years who received early postoperative enteral nutrition. A total of 76 subjects were randomized into a standard-protein group (3.0 g/100 mL) or a high-protein group (4.35 g/100 mL). Nitrogen balance was assessed on days 1 and 3, while I-FABP levels were measured before and after 72 h of enteral feeding.
Results
The high-protein group showed a significantly greater increase in average nitrogen balance (283.4 [standard deviation, 82.5] mg/kg/day) compared to the standard-protein group (114.7 [standard deviation, 53] mg/kg/day) (p < 0.0001). However, no significant decrease in I-FABP levels was noted in either group despite the above- and below-average nitrogen balance improvements.
Conclusion
High-protein enteral supplementation improves nitrogen balance in postoperative critically ill children without causing adverse side effects.
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| Key Words:
Protein, Supplement, Enteral nutrition, Critical illness, Pediatric intensive care unit |
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