| Effect of hyperglycemia on mortality rates in critically ill children |
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Seongkuk Kim1, Bo Eun Kim1, Eun Ju Ha1, Mi Young Moon2, Seong Jong Park1 |
1Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Pharmacy, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
| 소아 중환자에서 고혈당과 사망률과의 관계 |
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김성국1, 김보은1, 하은주1, 문미영2, 박성종1 |
1울산대학교 의과대학 서울아산병원 소아청소년과
2울산대학교 의과대학 서울아산병원 약제팀 |
Correspondence:
Seong Jong Park, Email: drpsj@amc.seoul.kr
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Received: 11 March 2009 • Revised: 13 July 2009 • Accepted: 13 January 2010 |
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| Abstract |
Purpose
: To verify the effect of hyperglycemia on mortality rates in critically ill children and to identify the blood glucose level that influences prognosis.
Methods
: From July 2006 to June 2008, a total of 206 patients who were admitted to the pediatric intensive care unit (PICU) at Asan Medical Center and who survived for more than 7 days were retrospectively reviewed. We analyzed the maximum glucose value within 7 days in PICU, PRISM-III score and SOFA score within 24 hours, and mortality. We did not perform an adjustment analysis of drugs affecting glucose level.
Results
: The maximum glucose level within 7 days in PICU was higher in the nonsurvival group than in the survival group. Using 4 cutoff values (125, 150, 175, and 200 mg/dL), the mortality of patients with hyperglycemia was found to be 13.0 %, 14.4%, 19.8%, and 21.1%, respectively, and the cutoff values of 175 and 200 mg/dL revealed significant differences in mortalities between the hyperglycemic and normoglycemic groups. The PRISM-III score was not significantly different between the hyperglycemic and normoglycemic groups under a glucose cutoff value of 175 mg/dL, but the SOFA score was higher in the hyperglycemic group. Under a glucose cutoff value of 200 mg/dL, the PRISM-III score was higher in the hyperglycemic group, and the SOFA score did not differ between the 2 groups.
Conclusion
: Hyperglycemia with a maximal glucose value ≥175 mg/dL during the first 7 days after PICU admission was associated with increased mortality in critically ill children. |
| Key Words:
Hyperglycemia, Glucose, Children, Pediatrics, Pediatric intensive care, Mortality, Survival |
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