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Artificial Intelligence in Pediatric Healthcare: current applications, potentials and implementation considerations

Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2025.00962    [Accepted]
Published online June 25, 2025.
Artificial Intelligence in Pediatric Healthcare: current applications, potentials and implementation considerations
Taejin park1,2  , In-Hee Lee2  , Seung Wook Lee3  , Sek Won Kong2,4 
1Department of Surgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea
2Computational Health Informatics Program, Boston Children’s Hospital, Boston, United States
3Department of Internal Medicine,MetroWest Medical Center , Boston, United States
4Department of Pediatrics, Harvard Medical School, Boston, United States
Correspondence: 
Taejin park, Email: taejin.park@childrens.harvard.edu
Received: 25 April 2025   • Revised: 17 May 2025   • Accepted: 19 May 2025
Abstract
Artificial intelligence (AI) has transformed pediatric healthcare by supporting diagnostics, personalized treat­ment strategies, and prognosis predictions. Although it offers significant promise in these areas, its application in pediatric settings poses distinct challenges compared with that in adults due to variable developmental status, the limited availability of pediatric data, and ethical con­cerns regarding bias and transparency. This narrative review summarizes the key concepts of AI and its clinical applications across clinical fields in the treatment of children and adolescents. Here we highlight the emerging role of large language models in performing admini­strative tasks and clinical documentation and supporting decision-making. We also address the evolving impact of AI integration in surgical care as an example while exploring ongoing concerns regarding reliability and diagnostic safety. Furthermore, we survey AI-enabled medical devices and discuss the current regulatory frame­­works relevant to pediatric care. This review provides a balanced overview of opportunities and challenges from a pediatrician's standpoint and aims to facilitate effective alignment and collaboration with key stakeholders in pediatric healthcare. Pediatricians must implement AI solutions cautiously and accountably to avoid unintended harm and realize their potential.
Key Words: Artificial intelligence, Pediatrics, Large langu­age models, Stakeholders, Ethics


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