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"Most downloaded" Articles are from the articles published in 2022 during the last six months.
- Original Article
- Critical Care Medicine
- Timing of parenteral nutrition initiation in critically ill children: a randomized clinical trial (65 times)
- Nagwan Y. Saleh, Hesham M. Aboelghar, Nehad B. Abdelaty, Mohamed I. Garib, Asmaa A. Mahmoud
- Clin Exp Pediatr. 2023;66(9):403-411. Published online June 14, 2023
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Question: What is the ideal initiation timing of parenteral nutrition for critically ill children?
Finding: This randomized clinical trial of 140 children examined the effects of an early or late start of parenteral nutrition on mechanical ventilation need (primary outcome) and length of stay and mortality (secondary outcomes).
Meaning: Children who received early versus late parenteral nutrition had lower mechanical ventilation need and duration.
- Review Article
- Neonatology (Perinatology)
- Neurodevelopmental outcomes of preterm infants (60 times)
- In Gyu Song
- Clin Exp Pediatr. 2023;66(7):281-287. Published online December 30, 2022
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· Among survivors, 60.9% of infants born at 22 weeks’ gestation had moderate to severe impairments, whereas 50.3% born at 23 weeks’ and 42.2% at 24 weeks’ gestation had moderate to severe impairments.
· Moderate and late preterm infants reportedly have less severe disease than very preterm infants, but they still experience adverse neurodevelopmental outcomes.
· The careful follow-up and early detection of developmental problems in these patients are required.
- Infection
- Global varicella vaccination programs (59 times)
- Young Hwa Lee, Young June Choe, Jia Lee, Eunseong Kim, Jae Young Lee, Kwan Hong, Yoonsun Yoon, Yun-Kyung Kim
- Clin Exp Pediatr. 2022;65(12):555-562. Published online November 2, 2022
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It is important to evaluate its effectiveness at the national level and to determine the varicella vaccine schedule based on the evidence generated through the studies.
- Endocrinology
- Nonalcoholic fatty liver disease and insulin resistance in children (58 times)
- Kyungchul Song, Ho-Seong Kim, Hyun Wook Chae
- Clin Exp Pediatr. 2023;66(12):512-519. Published online January 9, 2023
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· The prevalence of pediatric nonalcoholic fatty liver disease (NAFLD) increased from 8.2% in 2009 to 12.1% in 2018 in Korea.
· Laboratory tests, biomarkers, and imaging studies are used for the early detection of NAFLD.
· Insulin resistance is closely related to NAFLD.
- Applications of genomic research in pediatric endocrine diseases (58 times)
- Ja Hye Kim, Jin-Ho Choi
- Clin Exp Pediatr. 2023;66(12):520-530. Published online June 14, 2023
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· Recent advances in molecular genetics have improved our understanding of pediatric endocrine disorders and are now used in mainstream medical practice.
· Genome-wide association studies can increase our understanding of the biological mechanisms of disease and inform new therapeutic options.
· The identification of founder mutations leads to the efficient localization of the genes underlying Mendelian disorders.
· Next-generation sequencing technologies benefit clinical practice and research of pediatric endocrinology.
- Neurology
- Gut microbiota affects brain development and behavior (56 times)
- Gun-Ha Kim, Jung-Ok Shim
- Clin Exp Pediatr. 2023;66(7):274-280. Published online November 8, 2022
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· The gut microbiota can alter a host’s brain development and behavior.
· Gut bacteria communicate with the brain via the microbiota-gut-brain axis.
· Fecal microbial transplantation is a promising treatment strategy for autism spectrum disorder.
- Original Article
- Other
- Virtual, augmented, and mixed reality: potential clinical and training applications in pediatrics (55 times)
- Suyoung Yoo, Meong Hi Son
- Clin Exp Pediatr. 2024;67(2):92-103. Published online May 24, 2023
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· Review of articles that investigated the applications of virtual, augmented, or mixed reality in pediatric clinical settings and in the training of pediatric medical professionals was conducted.
· A total of 89 studies were retrieved, with 36 randomized controlled trials.
· In most studies, intervention using the novel technology was at least as effective or more effective than the traditional method.
· Use of virtual, augmented, and mixed reality has potential in pediatrics.
- Review Article
- Immunology
- Systemic autoinflammatory disorders (55 times)
- Dae Chul Jeong
- Clin Exp Pediatr. 2023;66(10):432-438. Published online June 14, 2023
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· Systemic autoinflammatory disorders (SAID) are disorders caused by dysregulation of the innate immunity with genetic background, leading to recurrent episodes of systemic inflammation.
· SAID is characterized by recurrent acute inflammatory responses including fever or skin manifestations, unrelated with infection or malignancy.
· Diagnosis is based on family and long-term history with detailed clinical and laboratory manifestations during febrile periods.
- Allergy
- New approaches to immunotherapy in house dust mite allergy (54 times)
- In Sik Kim
- Clin Exp Pediatr. 2023;66(4):161-168. Published online October 25, 2022
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Allergen immunotherapy (AIT) has developed over the last few decades and has emerged as a promising treatment. House dust mite (HDM) is a target allergen in AIT, and various modified HDM allergens have been improved for their efficacy. Moreover, clinical trials have proved their significantly therapeutic effects in allergy. This article review focuses on HDM allergens developed for AIT efficacy,...
- Original Article
- General Pediatrics
- Gross motor dysfunction and balance impairments in children and adolescents with Down syndrome: a systematic review (53 times)
- Preyal D. Jain, Akshatha Nayak, Shreekanth D. Karnad, Kaiorisa N. Doctor
- Clin Exp Pediatr. 2022;65(3):142-149. Published online June 11, 2021
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Question: What are the primary motor and balance dysfunctions in children with Down syndrome?
Finding: These individuals have gross delays, altered balance, and inefficient compensatory mechanisms.
Meaning: Neuromuscular and musculoskeletal impairments due to the chromosomal abnormality lead to developmental delay. These children also exhibit poor balance with greater instability and inefficient compensatory mechanisms including altered center of pressure displacement and trunk stiffening that predisposes them to falls.
- Other
- Risk factors and screening timing for developmental dysplasia of the hip in preterm infants (53 times)
- Ga Won Jeon, Hye Jung Choo, Yong Uk Kwon
- Clin Exp Pediatr. 2022;65(5):262-268. Published online November 5, 2021
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Question: When is the best screening timing and what is the risk factor for developmental dysplasia of the hip (DDH) in preterm infants?
Finding: Ultrasonography performed earlier than 38 weeks of postmenstrual age caused unnecessary subsequent ultrasonography. DDH did not occur predominantly on the left side or in breech infants.
Meaning: The screening timing, etiology, and risk factors for DDH in preterm infants are somewhat different from those in term infants.
- Review Article
- Gastroenterology
- Current diagnosis and image-guided reduction for intussusception in children (53 times)
- Jisun Hwang, Hee Mang Yoon, Pyeong Hwa Kim, Ah Young Jung, Jin Seong Lee, Young Ah Cho
- Clin Exp Pediatr. 2023;66(1):12-21. Published online July 4, 2022
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· Intussusception, the most common cause of small bowel obstruction in young children, has an overall incidence in Korea of 28.3 cases per 100,000 person-years.
· Its cause is idiopathic inmost cases, although viral or bacterial gastroenteritis has beenpostulated as a cause. Approximately 4% of children have pathological lead points for intussusception, and Meckel’s diverticulum is the most common cause.
· Intussusception in preterm infants is extremely rare. Older children (>5 years of age) are at increased risk of pathological lead points.
- Editorial
- Endocrinology
- Bisphenol A leaching from polycarbonate baby bottles into baby food causes potential health issues (53 times)
- Ga Won Jeon
- Clin Exp Pediatr. 2022;65(9):450-452. Published online July 25, 2022
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Can bisphenol A (BPA) leach out from polycarbonate baby bottles into baby food? BPA and other toxic materials can leach out from baby bottles and increase the risk of various health problems, including endocrine disturbances. Although the use of BPA in baby bottles has been banned, many developing countries still use it, which can cause health issues. Thus, public awareness of this issue is required.
- Review Article
- Allergy
- Diagnosis and management of asthma in infants and preschoolers (52 times)
- Hai Lee Chung
- Clin Exp Pediatr. 2022;65(12):574-584. Published online April 19, 2022
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· Asthma in infants and preschoolers involves heterogeneous phenotypes.
· Asthma diagnosis is based on symptom patterns, therapeutic responses, and the presence of risk factors with careful consideration of differential diagnosis.
· Daily inhaled corticosteroid therapy remains the most effective strategy for managing persistent asthma symptoms irrespective of phenotype.
· Future research, including genetic and molecular studies, is needed to develop a clear definition of asthma and personalized therapeutic approaches.
- Clinical Note
- Neurology
- Expanding association between BICD2 variants and brain malformations and associated lissencephaly (52 times)
- Jaeso Cho, Haeryung Kim, Seoungbok Lee, Jihoon G Yoon, HyeJin Kim, Minhye Kim, Seoyun Jang, Woojoong Kim, Soo Yeon Kim, Jong Hee Chae
- Clin Exp Pediatr. 2024;67(1):54-56. Published online December 21, 2023
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- Review Article
- Nutrition
- Association of gut microbiota with obesity in children and adolescents (51 times)
- Ky Young Cho
- Clin Exp Pediatr. 2023;66(4):148-154. Published online November 16, 2022
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The gut microbiota is an emerging factor in the development of pediatric obesity, which is affected by renowned risk factors such as diet, lifestyle, and socioeconomic status. This review aimed to describe the association between the gut microbiota and childhood obesity.
- Macronutrients modified dietary intervention in the management of overweight/obese children and adolescents: a systematic review (51 times)
- Jihyun Park, Oh Yoen Kim
- Clin Exp Pediatr. 2024;67(4):191-200. Published online July 11, 2023
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· Dietary macronutrient modifications affect the body composition of and metabolic markers in children and adolescents.
· Hypocaloric diets, regardless of macronutrient composition, are reportedly effective for weight loss in obese children.
· Future interventional studies with meta-analyses that include Korean children and adolescents are needed to provide basic information applicable to this population.
- Original Article
- General Pediatrics
- Global relationship between parent and child obesity: a systematic review and meta-analysis (50 times)
- Ju Suk Lee, Mi Hyeon Jin, Hae Jeong Lee
- Clin Exp Pediatr. 2022;65(1):35-46. Published online March 29, 2021
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Question: Are parent and child obesity correlated worldwide?
Finding: Overweight and obese status of parents and children were significantly associated worldwide. The association between parent and child obesity was stronger in Asia than in Europe and the Middle East, and in high-income than in middle- and low-income countries.
Meaning: Childhood obesity is highly influenced by parental weight status, indicating that parents could play an important role in its prevention.
- Neonatology (Perinatology)
- Efficacy of body position on gastric residual in preterm infant: a systematic review and meta-analysis (50 times)
- Kurvatteppa Halemani, Alwin Issac, Sanjay Dhiraaj, Prabhaker Mishra
- Clin Exp Pediatr. 2023;66(6):262-270. Published online November 30, 2022
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Breastfeeding and it's tolerance are the positive indicators for preterm babies. Placing the preterm infant in the right lateral or prone position after feed had lesser gastric residual volume compared to placing them in left lateral or supine positions. The post-feed position is a vital element in enhancing feeding tolerance, mechanical functions of the gastrointestinal tract and the overall development of preterm infants.
- Gastroenterology
- Inferior vena cava to aorta ratio in dehydrated pediatric patients: a systematic review and meta-analysis (49 times)
- Gilbert Sterling Octavius, Michelle Imanuelly, Johan Wibowo, Nadia Khoirunnisa Heryadi, Melanie Widjaja
- Clin Exp Pediatr. 2023;66(11):477-484. Published online June 14, 2023
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Question: The inferior vena cava to aorta (IVC/Ao) ratio measured via ultrasound has been touted as a promising noninvasive technique to assess clinically significant dehydration in pediatric patients.
Finding: Our meta-analysis found that IVC/Ao ratio had a positive likelihood ratio of 3.2 (95% confidence interval [CI], 2.1–5.1) and negative likelihood ratio of 0.18 (95% CI, 0.12–0.28).
Meaning: Hence, IVC/Ao ratio is insufficient to exclude or confirm significant dehydration in pediatric patients.
- Review Article
- Endocrinology
- Genetic factors in precocious puberty (48 times)
- Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
- Clin Exp Pediatr. 2022;65(4):172-181. Published online October 18, 2021
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· Mutations in the kisspeptin (KISS1), kisspeptin receptor (KISS1R), makorin ring finger protein 3 (MKRN3), and delta-like homolog 1 (DLK1) genes are associated with idiopathic central precocious puberty (ICPP).
· A few genes related to pubertal onset have been implicated in ICPP.
· Epigenetic factors such as DNA methylation, histone posttranslational modifications, and noncoding ribonucleic acids may be related to ICPP
- Allergy
- Trends of vitamin D in asthma in the pediatric population for two decades: a systematic review (47 times)
- Myongsoon Sung
- Clin Exp Pediatr. 2023;66(8):339-347. Published online June 14, 2023
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· Vitamin D may affect asthma via multiple mechanisms, including lung and optimal immune system functions.
· Many clinical trials have demonstrated the beneficial effects of vitamin D on asthma onset and aggravation. However, definitive clinical trials are lacking, and reports have detailed contradictory effects of vitamin D in children with asthma.
· Some exciting reports stated that obesity and vitamin D deficiency are associated with increased asthma symptoms in the pediatric population.
- Original Article
- Developmental and Behavioral Medicine
- Impact of short and intensive art-based intervention on symptomatology and social interactions among children with autism spectrum disorder (47 times)
- Deldar Morad Abdulah, Bayar Mohammed Omar Abdulla, Pranee Liamputtong
- Clin Exp Pediatr. 2023;66(10):447-454. Published online September 14, 2023
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Question: Does a short and intensive art-based intervention affect symptoms and social interactions among children with autism spectrum disorder (ASD)?
Finding: The short and intensive art-based intervention did not affect symptoms in children with ASD level 2 or 3, including social awareness, social cognition, social communication, social motivation, and autistic mannerisms.
Meaning: The short and intensive art-based intervention did not improve the symptoms of patients with ASD.
- General Pediatrics
- Effect of maternal and child factors on stunting: partial least squares structural equation modeling (45 times)
- Agus Santosa, Essa Novanda Arif, Dinal Abdul Ghoni
- Clin Exp Pediatr. 2022;65(2):90-97. Published online May 4, 2021
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Question: What effects do maternal and child factors have on stunting? Are there significant indicators of stunting?
Finding: Child and maternal factors had 49.8% and 30.3% effects on stunting, respectively. The primary child factor was infant formula dose, while the primary maternal factor was nutritional status.
Meaning: More attention to nutritional status during pregnancy and ensuring the appropriate dose of infant formula at ages 6–24 months can prevent stunting.
- Editorial
- Pulmonology
- Wheezing in infants and preschoolers: phenotypes and treatment options (45 times)
- Jung Yeon Shim
- Clin Exp Pediatr. 2023;66(1):26-27. Published online December 6, 2022
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· Knowing who will develop into asthma or who will not is important to impose proper treatment and early intervention in a child with the first episode of wheezing.
· Phenotypes of severe bronchiolitis in less than 2-year-old children with first episode of wheezing were suggested for different treatment options
· RV-induced and/or atopy-associated severe wheezing in preschool children may benefit from early intervention of asthma treatment.
- Original Article
- Neonatology (Perinatology)
- Oral administration of bone marrow-derived mesenchymal stem cells attenuates intestinal injury in necrotizing enterocolitis (45 times)
- Yeong Seok Lee, Yong Hoon Jun, Juyoung Lee
- Clin Exp Pediatr. 2024;67(3):152-160. Published online February 19, 2024
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Question: What is the optimal dose of bone marrow-derived mesenchymal stem cells (BM-MSCs) for treating necrotizing enterocolitis (NEC), and is orally administered BM-MSC effective?
Findings: High (1×106 cells) or multiple BM-MSC doses showed similar effects as low (1×105 cells) doses of intraperitoneally administered BM-MSCs. Furthermore, orally administered BM-MSCs were as effective as intraperitoneally administered BM-MSCs.
Meaning: Orally administered low-dose BM-MSCs are a potential treatment for NEC.
- Review Article
- Neonatology (Perinatology)
- Pathophysiology, classification, and complications of common asymptomatic thrombocytosis in newborn infants (44 times)
- Ga Won Jeon
- Clin Exp Pediatr. 2022;65(4):182-187. Published online October 18, 2021
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· Thrombocytosis, common in newborns and infants (<2 years) (3%–13%), is caused by elevated thrombopoietin (TPO) concentrations.
· Serum TPO levels are significantly higher immediately to 1 month postnatal and decrease with age.
· Platelet counts are positively correlated with gestational age at birth and postnatal age.
· Thrombocytosis is more common in preterm than in term infants.
· Thrombocytosis in newborns is reactive and resolves spontaneously without complications.
- Original Article
- Gastroenterology
- Assessing indicators and clinical differences between functional and organic childhood constipation: a retrospective study in pediatric gastroenterology clinics (44 times)
- Hasan M. Isa, Fatema A. Alkharsi, Fatema A. Salman, Maryam S. Ali, Zahra K. Abdulnabibi, Afaf M. Mohamed
- Clin Exp Pediatr. 2023;66(7):296-306. Published online June 14, 2023
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Question: What causes childhood constipation, and what can predict organic constipation?
Finding: Constipation represents 14.7% of gastroenterology visits. Functional constipation is more common among constipation types, while organic constipation is more common in young children and those with a low body weight, stunted growth, mucus in the stool, and associated diseases.
Meaning: Younger children and those with lower growth or mucus in the stool should be assessed for underlying organic causes of constipation.
- Review Article
- Neurology
- Big data analysis and artificial intelligence in epilepsy – common data model analysis and machine learning-based seizure detection and forecasting (42 times)
- Yoon Gi Chung, Yonghoon Jeon, Sooyoung Yoo, Hunmin Kim, Hee Hwang
- Clin Exp Pediatr. 2022;65(6):272-282. Published online November 26, 2021
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· Big data analysis, such as common data model and artificial intelligence, can solve relevant questions and improve clinical care.
· Recent deep learning studies achieved 0.887–0.996 areas under the receiver operating characteristic curve for automated interictal epileptiform discharge detection.
· Recent deep learning studies achieved 62.3%–99.0% accuracy for interictal-ictal classification in seizure detection and 75.0%– 87.8% sensitivity with a 0.06–0.21/hr false positive rate in seizure forecasting.
- Original Article
- Cardiology
- Effect of face mask on pulmonary artery pressure during echocardiography in children and adolescents (42 times)
- Alireza Ahmadi, Mohammad Reza Sabri, Zohreh Sadat Navabi
- Clin Exp Pediatr. 2024;67(3):161-167. Published online January 23, 2024
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Question: Can face masks alter pulmonary pressure in children and adolescents with and without congenital heart disease?
Findings: Mask removal during echocardiography (ECHO) reduced pulmonary pressure.
Meaning: These findings suggest that face masks should be removed during ECHO in children and adolescents.
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
