A Study on Serum Immunoglobulins and Complements in Newborn Infants by Gestational Weeks |
Ji Eun Lee, Kyung Hyo Kim, Kyung Hee Kim |
Department of Pediatrics, Ewha University, College of Medicine, Seoul, Korea |
재태주령에 따른 신생아 혈청 IgG, IgA, IgM 및 C3에 관한 연구 |
이지은, 김경효, 김경희 |
이화대학교 의과대학 소아과학교실 |
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Abstract |
The author investigated serum immunoglobulin (IgG, IgA, and IgM) and complements (C3) of cord blood in 74 cases of normal fulterm infants and 50 cases of premature infants. Serum immunolglobulin and complement levels were measured by the single radial immunodiffusion method.
The following results were obtained ;
1) The mean serum IgG levels of cord blood in 74 cases of the normal full term infants was 1407.3¡¾230.5mg/dl.
2) The mean serum IgG levels of cord blood in 50 cases of the premature infants was 675.2¡¾329.4mg/dl., In comparison of serum IgG levels between the premature infants and the normal full term infants, serum IgG levels in the premature infants was significantly lower than that level of the normal infants(P<0.05).
3) The serum IgA levels measured in 28(37.8%) of 74 cases of the normal full term infants and in 6(12%) of 50 cases of the premature infants. The seurm IgA levels measured ranged from 0.4mg/dl to 3.7mg/dl in the normal full term infants and ranged from 0.4mg/dl to 2.4mg/dl in the premature infants.
4) The mean serum IgM levels of cord blood in 74 cases of the normal full term infants was 4.05¡¾3.53mg/dl and that in 50 cases of the premature infants was 2.20¡¾2.15mg/dl
5) The mean serum C3 levels of cord blood in 74 cases of normal full term infants was 49.7¡¾18.1mg/dl and those of the premature infants was 30.9¡¾10.5mg/dl. In comparison of serum C3 levels between the premature infants and the normal full term infants, the mean levels of serum C3 in the premature infants was significantly lower.
A statistically significant increase of IgG and C3 levels of cord blood in newborn infants were observed in accordance with the increase of the gestational age. It has been suggested that decreased IgG levels among premature infants may provide a rationale for prophylactic gamma globulin administration. |
Key Words:
Serum immunoglobulin, complement |
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