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A Study on Prognostic Factors in Children with Encephalopathy

Journal of the Korean Pediatric Society 1994;37(12):1738-1745.
Published online December 15, 1994.
A Study on Prognostic Factors in Children with Encephalopathy
Jin Nyoung Park, In Joon Seol
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
급성 뇌병증 환아의 예후에 대한 임상적 연구
박진녕, 설인준
한양대학교 의과대학 소아과학교실
To elucidate the clinical characteristics-especially its clinical pattern and outcome of chidren with encephalopathy, we carried out a retrospective review on medical records of 45 patients who were intially diagnosed as encephalopathy except mumps meningitis, Reye's syndome and neonatal hypoxic ischemic encephalopathy at the Department of pediatrics, Hanyang University children's hospital from January 1986 to February 1994. The results were summerized as follows: 1) Twenty five were male and twenty were female with male to female ratio 1.3:1. 2) There were no association with death rate and conscious level, abnormal liver function test, and sugar level in CSF on admission. 3) Death rate(33.3%) of group with seizure was higher than that (13.3%) of group without seizure on admission, but there was no statistical significance(p=0.28). 4) Death rate(7.5%) of group (I) which initial therapy started before 12 hours was lower than that (43.4%) of group (II) which initial therapy started after 12 hours, but there was no statistical significance (p=0.09). However complete recovery rate (66.7%) of the former group was higher than that(26.7%) of the latter group with statistical significance (p<0.05). Therefore, early diagnosis and treatment before 12 hours was essential to recovery and good prognosis in children with acute encephalopathy.
Key Words: Acute Encephalopath, Prognostic Factors

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