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Change of Coronary Arterial Distensibility by Intravenous Infusion of Adenosine in Kawasaki Disease Patients Who Had Coronary Artery Aneurysm

Journal of the Korean Pediatric Society 1995;38(10):1363-1369.
Published online October 15, 1995.
Change of Coronary Arterial Distensibility by Intravenous Infusion of Adenosine in Kawasaki Disease Patients Who Had Coronary Artery Aneurysm
Myung Chul Hyun
Department of Pediatrics, KyungPook National University, College of Medicine, Taegu, KoreaPusan
관상동맥류가 있었던 Kawasaki병 환아에서 Adenosine에 의한 관상동맥 팽창성의 변화
현명철
경북대학교 의과대학 소아과학교실
Abstract
Purpose
: To investigate the effect of Kawasaki disease on coronary arterial distensibility, we studied 14 patients with Kawasaki disease who had had coronary artery aneurysms(mean of 4.5years have elapsed after onset of Kawasaki disease).
Methods
: Using Hewiett Packard-1500 echocardiogram, we measured RR interval, BP(blood pressure), EDD(end diastolic dimension), ESD(end systolic dimension), FS(fractional shortening), LVPWT(left ventricular posterior wall thickness), peak systolic wall stress, Vmcf(mean velocity of circumferential fiber shortening) and dimension of LM(left main coronary artery) and LAD(left anterior descending coronary artery), before and during intravenous adenosine infusion(150μg/minute/kg).
Results
: Before adenosine infusion, systolic BP was significantly increased in Kawasaki disease, being 112±8mmHg(p<0.05) compared with that in the control group. 104±9mmHg, Diastolic BP was also significantly increased in Kawasaki disease, Being 73±8mmHg(p<0.05) compared with that in the control, 66±8mmHg, Dimensions of LM and LAD were significantly increased in Kawasaki disease, being 3.76±1.06mm(p<0.01) and 2.54±0.99mmOp<0.05) respectively, compared with those in the control group, 2.25±0.56mm and 1.86±0.61mm respectively. During adenosine infusion, distensibility of LM was significantly decreased, being 5.2±6.5%(p<0.01) in Kawasaki disease compared with that in the control group, 31.2±26.7% Distensibility of LAD was also significantly decreased, being 5.4±2.3%(p<0.01) in Kawasaki disease compared with that in the control group, 38.8±29.4%.
Conclusion
: Abnormal distensibility of coronary artery persists for a long time after onset of Kawasaaki disease.
Key Words: Kawasaki disease, Distensibility of coronary artery, Adenosine


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