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Correlation between Plasma Endothelin-1 Concentrations and Pulmonary Hypertension Associated with Congenital Heart Defects

Journal of the Korean Pediatric Society 1996;39(7):970-976.
Published online July 15, 1996.
Correlation between Plasma Endothelin-1 Concentrations and Pulmonary Hypertension Associated with Congenital Heart Defects
Sang Ook Park, Su Eun Park, Hyang Jae Yoo, Young Tak Lim, Hee Ju Park
Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea
선천성 심질환을 가진 환아에서 폐동맥 고혈압증과 혈중 Endothelin-1과의 상관 관계
박상욱, 박수은, 유황재, 임영탁, 박희주
부산대학교 의과대학 소아과학교실
Abstract
Purpose
: Endothelin-1 is the most potent vasoconstrictor. This study was investigated the correlation of plasma endothelin-1 and pulmonary hypertension associated with congenital heart defect.
Methods
: We evaluated the concentration of ET-1 in 24 cases of congenital heart disease diagnosed at the Department of Pediatrics, Pusan National University, from December 1993 to September 1994. The patients were divided into 2 groups according to mean pulmonary arterial pressure: Pulmonary artery hypertension group(Group Ⅰ) and normal pulmonary artery pressure group(Group Ⅱ). Between 2 groups, there was no statistical significance in mean age, sex and oxygen saturation. GroupⅠ included 9 patients of VSD and 1 patient of COA. Group Ⅱ included 9 patients of VSD, 3 patients of TOF and 1 patient of PS, 1 patient of PS with DORV.
Results
: The results were summarized as follows; 1) The mean pulmonary arterial pressure and pulmonary-to-systemic flow ratio (Qp/Qs), pulmonary vascular resistance in GroupⅠwere significantly higher than those in Group Ⅱ. 2) The plasma concentrations of ET-1 in GroupⅠ was significantly higher than those in Group Ⅱ. 3) But there were no statistical significance between the concentrations of ET-1 and the mean pulmonary artery pressure, Qp/QS, pulmonary vascular resistnace.
Conclusion
: Based on these results, plasma ET-1 concentraions were elevated in patients with pulmonary hypertension associated with congenital heart defects.
Key Words: Endothelin-1, Pulmonary hypertension, Congenital heart defect


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