| A Study about IgG Subclasses Concentration of Chronic Cough Patient and Changes of Immunoglobulin Levels after RU 41.740 Administration |
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Yun Sun Choi, Yang Woo Kim, Seok Jung Yun, Hyung Ku Cho, Kee Hyuck Kim |
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Department of Pediatrics, Konkuk University Hospital, Chungju, Korea |
| 만성기침 환아의 혈청 IgG 아형농도 및 RU 41.740 투여 후 변화에 관한 연구 |
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최윤수, 김양원, 윤석중, 조형구, 김기혁 |
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건국대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: People who suffer from chronic or recurrent respiratory disease have immunoglobulin
deficiency due to hypofunction of B cell. Among these immunoglobulin deficiency, it has been
reported that only one or two subclass of IgG are deficient with normal quantity of IgG and
IgA. Therefore it is necessary to measure IgG subclasses in chronic or recurrent respiratory
infection for diagnosis. The purpose of this study is to measure IgG subclass in children with
chronic respiratory disease and administration of RU 41.740 which was obtained from Klebsiella
pneumonia, K2O strain(it has proven role in control of immunity) comparing the changes of
immunoglobulin levels and IgG subclasses with the control group. So that better therapeutic
approaches can be made for these diseases.
Subjects and Methods : Thirty-six patients who visited to Konkuk university hospital due to
chronic and recurrent coughing from January 1993 to June 1994, were selected for this research.
Their age ranged from 2～13 year old and patients with evident history of allergy or tuberculosis
were excluded. RU 41.740 with antibiotics were given to 31 subjects and 5 subjects were given
placebo with antibiotics. For all subjects IgG, A, M, E, IgG1, G2, G3, G4 were measured.
Immunoglobulins were remeasured from 15 subjects who received RU 41.740 and from 5
subjects who received placebo.
Results
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1) Five subjects out of 36 were low or low-normal IgG group and all combined with IgG
subclass deficiency, and all of low or low-normal IgG group had IgG3 deficiency. Eighteen
subjects out of 31 normal IgG group accompanied IgG subclass deficiency and 12 subjects had
IgG3 deficiency, which is most common IgG subclass deficiency.
2) Four subjects out of 36 were IgA deficiency group. Three subjects from 4 accompanied
IgG subclass deficiency and had IgG4 subclass deficiency.
3) After the RU 41.740 administration, the levels of IgG and IgG subclasses increased
significantly in study group. There were no significant change in IgG and IgG subclasses levels
in placebo group
Conclusion
: In patients with chronic or recurrent respiratory disease, it is necessary to
measure IgG subclass. These diseases tend to be chronic and recurrent and can be severely
complicated causing bronchiectasis and incurable otitis media. Generally these diseases are not
responsive to antibiotics. Therefore therapies should be directed to increasing immunological
function for better results. |
| Key Words:
Chronic cough, IgG subclass, RU 41.740 |
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